Hypomyelinating (dysmyelinating) leukodystrophy. Unknown mutated gene. #Leukodystrophy #hypomyelinatingdisease #myelin #pediatricneurology #neurology #neuroradiology #radiology #NeuroTwitter #MedEd

Steroid-responsive brain inflammatory process Reminiscence of CLIPPERS. Atypical location, as here, the pons didn´t have any abnormal signal. Brain biopsy was negative for demyelination and it showed perivascular&parenchymal lymphocytic infiltrates. GFAP ab negative. #neurology

Metachromatic leukodystrophy · Autosomal recessive. Mutation in the ARSA gene leads to arylsulfatase A deficiency. Lysosomal storage disease. · U-fibers are initially spared #metachromaticleukodystrophy #arylsulfataseadeficiency #lysosomalstoragedisorder #neurology #Pediatrics

Acute necrotizing encephalopathy of childhood (ANEC) #acutenecrotizingencephalopathyofchildhood #ANEC #ADEMlike #neuroimmunology #neurotwitter #MedEd

Parry Romberg syndrome Slowly progressive facial hemiatrophy. It can be associated with brain changes as well. Etiology unknown but thought to be autoimmune. Patients can present with seizures and migraines. Green arrows show asymmetry between both sides. #Neurology