🧪 February's most-read Biochemistry paper reconstructs the genome of #YerbaMate for the first time, teaching us about the convergent evolution of #caffeine: elifesciences.org/articles/10475…

A team of scientists have unearthed an ancient lagoon ecosystem in Northern Patagonia, uncovering hundreds of fossils. Among them is the discovery of a new dinosaur species, Chadititan calvoi: on.natgeo.com/3XKLyjj

Does anyone have good P2RY12 antibodies that they use for IHC that they can link us to for purchase? Many Thanks.

Human brain cells engineered to evade detection by the immune system have successfully restored muscle control in a rat model of Parkinson’s disease go.nature.com/4lwWD1F

Using direct, intracranial brain recordings in humans, a new study in Science finds that the thalamus, a small region located deep within the brain, plays a pivotal role in conscious perception. scim.ag/3R9rRhd

Spatial transcriptomics of the aging mouse brain reveals origins of inflammation in the white matter | Nature Communications nature.com/articles/s4146…

We are excited to launch our lab website today! Visit our homepage here: alvarezparilab.com We are recruiting postdoctoral researchers (starting Fall) for our lab at UVA! More information about the position: uva.wd1.myworkdayjobs.com/UVAJobs/job/Ch…

Still in 2021, in a study led by Eyo et al. from Wu Lab at UTHealth lab, we learned about microglial process pouches that wrap around injured dendrites following severe seizures and were suggested to provide neuroprotective functions:cell.com/cell-reports/f….🤩#20YearsInVivoMGImaging

STING deletion protects against amyloid β–induced Alzheimer's disease pathogenesis alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Hay tanto amor en la paciencia.

To wrap up this series, this year (2025) in a soon-to-be-published study, Tré Mills is revealing that microglia (rather than BAMs) maintain basal capillary tone through vasodilatory COX1 signaling. A pre-print is available here: researchsquare.com/article/rs-614….🤩#20YearsInVivoMGImaging

Microglia feet are highly dynamic and can be in contact with dense networks of axons. In this video by our #ElectronMicroscopy team using MICrONS data, a microglia (purple) contacts with an excitatory pyramidal neuron (gold). Slowly the axons under the feet are revealed.

ShinyGO: a graphical gene-set enrichment tool for animals and plants Very convenient online platform for pathway enrichment & visualization, once you have your genes of interest😆 bioinformatics.sdstate.edu/go/ Steven Ge #Bioinformatics 2020 academic.oup.com/bioinformatics…

Hi friends- if you're interested in what I've been doing for the last 6+ years, I'm defending my dissertation on July 11th at 11am! Come tune in on zoom (message me for the link!) to hear about why we think matrix structures called #perineuronalnets are important in seizing mice.

Finally online today: nature.com/articles/s4146… Thanks to all involved, especially Eyo and the phenomenal undergraduates I've had the privilege to mentor. Also check out two of my other recent publications. 1) pmc.ncbi.nlm.nih.gov/articles/pmid/… 2) onlinelibrary.wiley.com/doi/full/10.11…

Amazing #2PM real-time morpho-dynamic responses of #Microglia to focal, laser-induced parenchymal or vascular injury in neonatal vs adult vs aged mouse brain Reaction speed 👉Parenchymal injury: Adult > Aged/Neonatal 👉Vascular injury: Adult/Aged > Neonatal What molecules

In the latest issue! Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes dlvr.it/TM8GVY

Exciting news! We are translating our brain colouring book to Spanish. 📚 ✨ Tag a friend that speaks Spanish! Comment below or send us a private message if you’d like to help edit and test out our book. ✏️ 🧠 📖

🔥 #FluorescentFriday spotlight! Green: NeuN Yellow: Perineuronal nets (PNNs) 🛡️ Magenta: c-Fos ⚡️

Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors nature.com/articles/s4158…