I had so much fun writing this Research Highlight for Nature Methods. Researchers from Peking University were able to culture human totipotent blastomere-like cells through splicing inhibition. RH: doi.org/10.1038/s41592… Original paper in Cell: doi.org/10.1016/j.cell…

For her story Vivien Marx🐘📬⛅️ spoke with NSF Director Sethuraman Panchanathan Sandra Wachter - @[email protected] J.Richer Florian Jug Wolfgang Huber 🇺🇦 Jeremy Y. Ng and others about emerging best practices in AI. nature.com/articles/s4159…

The entire collection of Focus of advanced AI in biology pieces can also be found here: nature.com/collections/ah… We thank all of our authors for their fantastic contributions!

🔬 Bridget Carragher, Pratibha Gai, & Kostya Novoselov headline the 3rd Frontiers in Electron Microscopy for Physical and Life Sciences Nature Conferences! Early bird registration & abstract submission ends on August 26. Register now ➡️ go.nature.com/3QjPiV0

Research Highlight by Lei Tang: a CHARMing epigenetic silencer. Original paper: science.org/doi/10.1126/sc… Highlight: nature.com/articles/s4159…

Research Highlight by Arunima Singh: a conditional protein trans-splicing approach to alter protein function and localization. Original paper: nature.com/articles/s4158… Highlight: nature.com/articles/s4159…

Research Highlight by Nina Vogt: virtual models of rats can be used to simulate behaviors and gain insights into the underlying neural activity. Original paper: nature.com/articles/s4158… Highlight: nature.com/articles/s4159…

We have partnered with Nature Materials, Nature Catalysis, nature and @NatureMethods for the @Natureconf 3rd Frontiers in Electron Microscopy for Physical and Life Sciences. Join experts in electron microscopy instrumentation and methods this October 16-18!

This Perspective from Qing Nie, Fabian Theis, Xiangmin Xu and colleagues discusses the integration of small-scale datasets with each other or with larger reference atlases, particularly in the context of single-cell approaches. nature.com/articles/s4159…

Research Highlight by Rita Strack Kwanghun Chung and his research team have developed an end-to-end pipeline for preparing, labeling, imaging and ultimately mapping human brain tissue. Highlight: nature.com/articles/s4159… Research paper: science.org/doi/10.1126/sc…

Out last week from the Bayrakter and Hannifa labs! WebAtlas offers user-friendly sharing and interactive navigation of integrated single-cell and spatial transcriptomic datasets. nature.com/articles/s4159…

A Comment by Samira Musah and Hamidreza Arzaghi discusses the role of engineered biomaterials as tunable platforms for optimal organoid differentiation. nature.com/articles/s4159…

Out today from the labs of Xinlei Wang, Yang Xie, and Tao Wang! Spacia is a multiple-instance learning model for cell–cell communication (CCC) interference in single-cell resolution spatially resolved transcriptomics data. nature.com/articles/s4159…

Check out CellPainting Gallery from Erin Weisbart, Shantanu Singh and colleagues, a publicly available collection of Cell Painting datasets with granular dataset descriptions and comprehensive documentation. Erin Weisbart (she/her) Shantanu Singh nature.com/articles/s4159…

A workflow integrating imaging mass cytometry and mass spectrometry-based imaging on the same tissue sample, developed by de Miranda Lab, enables analysis of metabolic heterogeneity at the single cell level. Marieke Ijsselsteijn Joana Nunes Noel F. de Miranda nature.com/articles/s4159…

The SplitsTree App facilitates comprehensive, proficient and reproducible phylogenetic tree and network analysis. Daniel Huson nature.com/articles/s4159…

Collaborative Augmented Reconstruction is a platform for large-scale reconstruction of neurons and other cells from multi-dimensional imaging datasets. It can be accessed from a variety of devices simultaneously for efficient and accurate reconstruction. nature.com/articles/s4159…