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Casali and colleagues describe a mouse model with a human lymphoid and myeloid immune system, that expresses BCR and TCR repertories as diverse as humans and mounts antibody responses to infection and vaccination. Read it here: rdcu.be/dLY2o nature.com/articles/s4159…

Congratulations to all of the trainee winners Aegean Conferences #fibroblasts #mesenchyma_cells #stromal_immunology

Great group photo of all the attendees at the Aegean Conference on Mesenchymal Cells in Health and Disease.

Dong and colleagues describe the reciprocal regulation of TFH cells and DCs in colonic lymphoid follicles and how this promotes colitis. Read it here: rdcu.be/dM6SA nature.com/articles/s4159…

Malmberg and colleagues provide a single-cell transcriptional reference map of healthy human NK cells and use this profile of tumor infiltrating NK cells. Read it here: rdcu.be/dM6V4 nature.com/articles/s4159…

Vivier and colleagues integrated scRNA-seq and CITE-seq data to provide a resource of human NK cell heterogeneity in healthy tissues and in the tumor setting. Read it here: rdcu.be/dM61D nature.com/articles/s4159…

Colonna and colleagues provide a resource of ILC1 heterogeneity in human tissues. Read it here: rdcu.be/dM64F nature.com/articles/s4159…

Kreslavsky and colleagues describe a role for thymic innate-like T cells in tolerance by direct antigen presentation to autoreactive CD8+ T cells. Read it here: rdcu.be/dP2f6 nature.com/articles/s4159…

Seshadri and colleagues find that resistance to infection with Mycobacterium tuberculosis is associated with CD4+ T cells with of TH17 and regulatory T cell-like functional programs. Read it here: rdcu.be/dP2iP nature.com/articles/s4159…

Regev and colleagues describe the role of BACH2 in promoting immunomodulatory Th17 cells. Read it here: rdcu.be/dP2m6 nature.com/articles/s4159…

Uldrich and colleagues describe the crystal structure of the Vγ9Vδ2 TCR interacting with BTN2A1. Read it here: rdcu.be/dP2nH nature.com/ni/research-ar…

Muppidi and colleagues find that loss of the G-protein Gα13 suppressed diffuse large B cell lymphoma formation in the mesenteric lymph nodes by limiting the effects of dietary nutrients. Read it here: rdcu.be/dQFmi nature.com/articles/s4159…

Vinuesa and colleagues identify patients with a pathogenic variant in TNIP1 that resulted in B cell mediated autoimmunity by enhancing IFN1 signaling and reducing mitophagy. Read it here: rdcu.be/dQFpE nature.com/articles/s4159…

Marie and colleagues identify a population of tumorigenic Th17 cells in the intestine. Read it here: rdcu.be/dQFtx nature.com/articles/s4159…

Pinho and colleagues identified a serum glycome signature on circulating antibodies IgGs detectable up to 6 years before Crohn’s disease diagnosis. Read it here: rdcu.be/dQFvn nature.com/articles/s4159…

Sun and colleagues suggest that nucleophosmin 1 expression in ILC3s regulates IL-22 production and mitochondrial function and is required for gut homeostasis and colitis prevention. Read it here: rdcu.be/dQQhI nature.com/articles/s4159…

Zhou and colleagues suggest that the p97–Npl4 complex promotes the differentiation and recruitment of tumor infiltrating Tregs and this can be blocked with thonzonium bromide. Read it here: rdcu.be/dQQjs nature.com/articles/s4159…

Irvine and colleagues suggest that targeting IL-12 and IL-15 to CD45 is an effective antitumor treatment and limits adverse effects associated with cytokine therapies. Read it here: rdcu.be/dQQkz nature.com/articles/s4159…

Dudakov and colleagues report the age-associated emergence of unique TEC states linked with tissue degeneration. Read it here: rdcu.be/dQQla nature.com/articles/s4159…

SAVE THE DATE May 15-20, 2025 - 20th International Conference on #InnateImmunity in #Sissi #Crete #Greece at the Kalimera Kriti Conference Center aegeanconferences.org/src/App/confer…