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Thrilled to share our new preprint on using a new type of microbial memory to track horizontal gene transfer in environmental microbial communities. Amazing collaboration with Chappell Lab and Joff Silberg labs. biorxiv.org/content/10.110… (1/n)

1/11 - With Karin Mitosch and Clément Potel + colleagues in Savitski Lab Typas Lab EMBL, I’m very happy to share our discovery of a hyper-promiscuous phage protein kinase (T7K) which broadly deactivates bacterial defenses! biorxiv.org/content/10.110…

Pls share: Postdoc position in microbiology with a focus on antibiotic heteroresistance

JOB ALERT! Full Professorship (W3) in Molecular Biology (f/m/d) with a Focus on Biological Engineering in Heidelberg Vacature closes 1st February! GASB SynBio nature.com/naturecareers/…

Nature research paper: De novo designed proteins neutralize lethal snake venom toxins go.nature.com/4jt16RY

Our lab is recruiting postdocs with strong expertise in molecular microbiology and/or phage biology to work on different antibiotics-related projects (more info epfl.ch/labs/upgoemans/). Please get in touch if interested (with CV and references)!

1/14 Excited to share our new ElinavLab Microbiome & Cancer Elinav Lab at DKFZ Weizmann Institute paper Cell, championed (for 6 years!) by the amazing Rafael Valdés, Avner Leshem, Danping Zheng and twitter-less Alon Savidor. In this work, we’ve adopted into microbiome.. cell.com/cell/fulltext/…

I'm thrilled to announce our latest work is now published in Cell! Viruses encode numerous proteins that inhibit host defenses, but identifying immune-modulatory proteins among millions of viral sequences has been nearly impossible - until now! cell.com/cell/fulltext/…

Happy to share our latest findings on Kiwa. Foundational work from Thomas, with Zhiying and Yi providing beautiful structures and molecular insights. Ever grateful for the collaborations with Eugene and Dinshaw. More to come 🙃 doi.org/10.1101/2023.0…

🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with Freya Harrison. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44

Very happy our paper on CARD domains in gasdermin anti-phage defense systems is now published in nature 🥳 Thanks to all the people involved especially the Kranzusch lab and Sorek Lab nature.com/articles/s4158…

Now published Science Magazine: TIR signaling activates caspase-like immunity in bacteria We report a new immune molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase Congrats @FrancoisRousset & Ilya Osterman! science.org/doi/10.1126/sc…

🚨 🧬 Updated preprint on the completed BASEL collection - what's new? Some fun with bacterial immunity and a new P22 relative infecting E. coli K-12. A thread 🧵

Prof. Martin Steinegger's team at SNU has developed Foldseek-Multimer, a rapid and highly sensitive protein complex structural aligner. This breakthrough allows for the comparison of billions of complex pairs in just 11 hours. By computing complex alignments, Foldseek-Multimer

Nature research paper: Limited impact of Salmonella stress and persisters on antibiotic clearance go.nature.com/4goUaCp

ActSeek: Fast and accurate search algorithm of active sites in Alphafold database 1. ActSeek introduces a novel approach to searching protein databases for similar active sites using a fast algorithm inspired by computer vision, enhancing the search for proteins with specific

So happy that I can finally share the results of my first postdoc paper with Michael Baym!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics! Here’s a photo of plasmids competing inside cells in a colony (1/n)

It is finally out! Muntathar Al-Shimary, Doudna Lab, Brady Cress and I present a gene knockdown tool that works in diverse phages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)! Check out the final paper in Nature Microbiology nature.com/articles/s4156…

We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their

Please repost: Postdoc position in antibiotic discovery in a multidisciplinary project w. high-throughput approaches, microscopy, AI, and hit-to-lead optimization Université de Montréal Faculté de médecine Mila - Institut québécois d'IA IRIC. Apply @ [email protected]. See lnkd.in/dVVk4N3s