Great teaching points from @ADamronMD - If you are trying to differentiate between - Tubular adenoma - Sclerosing Adenosis - Adenomyoepithelioma Please read this🔑🔑🔑🔑🔑🔑🔑🔑🔑🔑🔑🔑 #breastpath

62 yo female, Right Breast mass Solid papillary carcinoma with reverse polarity (SPCRP)

Yippee. Look what I woke up to . A beautiful morning indeed. #BreastPath

Perforating folliculitis, H&E and Masson's Trichrome.

45/F left breast mass. HER2 IHC equivocal. Dual ISH showing polysome of chromosome 17. #Breastpath

This gland lacks a myoepithelial layer—should we call it microinvasive cancer? No. Why? Because we assess in 2D, but glands are 3D. The plane of section may miss myoepithelial cells. Loss of p63 doesn’t always mean cancer. See last slide of independent p63 #breastpath

Let’s review breast lesions that present as asymmetries on mammography this week! Case of Radial Scar🔬 Radial scar show radiating proliferative fibrocystic changes surrounding a fibroelastotic nidus that can appear as an asymmetry. #PathX #PathTwitter #breastpath #radpath

Breast, 70s, If you had one IHC, what would it be?😃Dr. Luca Olaleke Folaranmi Fouad Boulos Raza Hoda MD Alexander Damron, MD Brian McMillen MD Liza Quintana, MD Tania Labiano Aurélien Morini, MD, MSc 🇫🇷🇪🇺💙💛 Celina Stayerman MD Nusrat Z. Bokhari Amal Asar, FRCPath, MAcadMED Tristan Rutland MBBS FRCPA IFCAP Israh Akhtar Khan Lorand Kis Padma Priya J Barry McGinn #breastpath

Let’s review papillary breast lesions this week! Case of Micropapillary Carcinoma 🔬 Classic cell clusters with ‘inside growth’ floating in empty spaces. Catch Problematic Papillary Proliferations with Patrick J. McIntire & me at #CAP25 next week! #PathX #PathTwitter #breastpath

Less common features seen in fibroadenomas - Irregular borders/fat entrapment - Stromal multinucleated cells - Chondroid metaplasia - Pregnancy secretory changes - Columnar cell changes - Atypical ductal hyperplasia - Intraductal papilloma - Sclerosing adenosis - Radial scar -

Fibroadenoma (cellular) vs benign phyllodes tumor If you have a fibroepithelial lesion that defies a final categorization after evaluating all the morphologic criteria (see pic 1) you can call it "benign fibroepithelial neoplasm/lesion" Dr Tan - Challenging Fibroepithelial

Grading of phyllodes tumor when histological criteria doesn't fit neatly into the assigned categories (see pic 1) . Phyllodes tumors WHO 5th edition 2019 Requires all 5 features to be present for a malignant phyllodes tumor diagnosis (pic 2) . Phyllodes tumors WHO 6th edition

Breast-Intraductal papilloma Features associated with upgrade to carcinoma - Age ≥50 yo - Mass and calcifications: 14.3% - Bloody nipple discharge: 12.5% - Peripheral location: 10.3% - Palpable mass: 9% - Size ≥ 1 cm: 7.3% - Calcifications: 8.3% Dr Brogi- Contemporary issues

In high-income countries, breast cancer 5-year survival is 90%+. India: 66% South Africa: 40% If trends continue, cases & deaths will rise 40% by 2050. Where a woman lives should never decide if she survives. #BreastCancerAwarenessMonth

Mucinous carcinoma- Breast Definition changes-6th edition (not published yet) - Special type of breast carcinoma caracterized by clusters of epithelial tumor cells suspended in pools of extracellular mucin with low to intermediate grade nuclei and no features of other IBC types

If there’s one thing I wish I had done differently when I was hit by a stroke last January, it would be to go to the hospital immediately, within the Golden Hour (<4.5 hours), instead of thinking I could just sleep it off. This “nothing will happen to me” attitude is common,