Just found a new and very comprehensive review from Pruneda Lab about ubiquitin-directed bacterial effectors. Highly recommended! embopress.org/doi/full/10.15…

Out now in NatComms: A Chlamydia-like bacterium with a deubiquitinase repertoire similar to Legionella, but using new DUB classes for the same linkage specificities (e.g. M1, K6). #ubiquitin Universität zu Köln Cologne Crystallisation facility doi.org/10.1038/s41467…

Now published: We analyzed the structure of the Burkholderia effector TssM with and without ubiquitin. TssM is a divergent member of the USP-type deubiquinases and can recognize #ubiquitin despite the lack of the 'fingers' domain. life-science-alliance.org/content/7/2/e2…

By the way: this project was the brainchild of excellent postdoc Thomas Hermanns, who was also corresponding author! We also acknowlegde support from Cologne Crystallisation facility and Universität zu Köln

Breite Wissenschaftler nutzen räumliche Transkriptom-Technologie, um eine Million Zellen im Nervensystem der Maus zu kartieren. (according to Google Translate -> German)

Iceland volcano eruption, live feed livefromiceland.is/webcams/fagrad…

TssM from Burkholderia pseudomallei reveals that TssM lacks the canonical 'Fingers' subdomain of USP-type deubiquitinases & evolved the functionally analog 'Littlefinger' loop instead for ubiquitin binding Hofmann_Lab Universität zu Köln bit.ly/46Wheny

📢📷EMBO Workshop on "Ubiquitin and ubiquitin-like proteins in health and disease", 27th September – 1st October 2024, in Cavtat-Dubrovnik, Croatia. #emboubiquitinFor more information and registration: meetings.embo.org/event/24-ubiqu… … Please share 📷 🙏

Do you love #genetics and have a #MSc in #biochemistry, #biology, or #biophysics? 🧬🌱Join Universität zu Köln in Germany as #research assistant in the DFG public | @[email protected]-funded network SFB_1403 on cell death in immunity, inflammation & disease! Apply by 04/02: stellenwerk.de/koeln/jobboers…

Two PhD positions in our research group! If you are interested to study the molecular mechanisms of necroptotic and pyroptotic cell death - and their relationship to plant cell death, do apply!

After a long time in the making, our study on bacterial clippases is finally available as a preprint biorxiv.org/content/10.110… These are really fascinating enzymes, for which there will be a ton of applications in studying the #ubiquitin system

While I understand and (partially) share the feeling, this kind of criticism is too simplistic. You might as well ask for Social network revenues and what they pay their users

Thanks for organizing this great meeting! There aren't that many opportunities where you can discuss cell death and defense strategies both with plant & animal researchers.

We discovered a new immune signaling molecule: N7-cADPR N7-cADPR is produced by phage-stimulated TIR proteins. It activates a bacterial caspase, which then degrades essential proteins to curb infection Preprint: biorxiv.org/cgi/content/sh… Congrats @FrancoisRousset & Ilya Osterman

New Lammers Lab paper out now in Nature Communications!🥳 We reveal high functional diversity within bacterial deac(et)ylases by systematic functional/structural characterization. This is Leonies PhD project and I’m grateful to have contributed to this great work. nature.com/articles/s4146…

The #AlphaFold 3 model code and weights are now available for academic use. We Google DeepMind are excited to see how the research community continues to use AlphaFold to address open questions in biology and new lines of research. github.com/google-deepmin…

Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology Nature Chemical Biology. Congratulations Kim, Kai, and all authors! nature.com/articles/s4158…

Lol who did this

Great paper, but sorry, this is *not* a CARD domain! It is a 6-helix death fold domain for sure, but there in no evidence provided that it belongs to the CARD subfamily. It might have (convergently?) acquired a similar function as mammalian caspase-associated CARDs. Just saying.

Our paper on bacterial clippases is now out in Molecular Cell. These really interesting enzymes can make deconjugation of #ubiquitin irreversible. Thanks to Universität zu Köln and Cologne Crystallisation facility for support. cell.com/molecular-cell…