So when does ecDNA arise, exactly? Our study on #ecDNA and the transformation of pre-cancerous Barrett’s esophagus into cancer is out today. This collaboration brought together @Team_eDyNAmiC, Rebecca Fitzgerald Lab and the @FredHutch Seattle Barrett’s Study.🧵 nature.com/articles/s4158…

Online at @nature: “Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus” by Mischel Lab and colleagues #ecDNA #cancer nature.com/articles/s4158…

Amazing! Octopus and squid use cephalopod-specific chemotactile receptors (CRs). The octopus CRs are more recently evolved and expressed on its arms, which allows it to 'taste by touch' nature.com/articles/s4158…

Out in nature today, we describe a new method "PACER" to estimate clonal expansion rate and use it to identify that aberrant TCL1A activation as a cause of #CHIP expansion and potential therapeutic target @J__Stock Jk Gopakumar Siddhartha Jaiswal nature.com/articles/s4158…

Excited to see several Nature Medicine #neoadjuvant #immunotherapy trials in #melanoma highlighted in the ongoing #AACR23 clinical trials plenary session! Check out our new collection & call for papers in this research area with nature and Nature Communications: nature.com/collections/eb…

Looking for something to read on the ✈️ home from #AACR23? Our April Nature Medicine issue is now live! The cover by Niamh Mundy & Marina Corral Spence highlights two of the #TRACERx #lungcancer studies. PLUS we have lots more #oncology #cancer research in this issue!

30. Nice summaries of today’s paper -> here from Dr. Neeha Zaidi nature.com/articles/d4158… -> here from Memorial Sloan Kettering Cancer Center mskcc.org/news/can-mrna-… And shareable link -> rdcu.be/dbPBq

Online at @nature: “Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer” by Vinod BalachandranMD nature.com/articles/s4158… #cancer #clinicaltrials

I’m delighted that our paper on the Multicellularity Long Term Evolution Experiment (MuLTEE) has, at long last, been published. This paper establishes the foundations of what I’d like to work on for the rest of my career. 1/25 Free, full access link: rdcu.be/dbPA9

I'm happy to share that our article, published in nature (nature.com/articles/s4158…), highlighting the mutations occurring in our colon due to "L1 jumping genes". Genomic mosaicism by L1 jumping begins during early development and continues throughout an individual's lifetime!

new out in Nature nature.com/articles/s4158…

new out in Nature nature.com/articles/s4158…

new out in Nature nature.com/articles/s4158…