Save Time: Convert SRA files to fastq files faster! youtube.com/watch?v=8OMbqX…

I was asked this question very often: “Tommy, what’s the p-value cutoff should I use to determine the differentially expressed genes; what log2 Fold change cutoff should I use too?” New blog post: Bioinformatics is not (just) statistics divingintogeneticsandgenomics.com/post/bioinform…

less taught computational skill: how to organize a computational biology project youtube.com/watch?v=wXXhp9… bonus: I will show you how I organize my project in Rstudio

🌟 NEW! We are super excited to announce our collaboration with Tinkle Magazine to bring you an inspiring series of comics featuring brilliant women scientists from our institute! 👩‍🔬 The first comic features Dr. Deepti Trivedi, who heads the Drosophila facility at NCBS.

Thank you IISc press for highlighting our work. All credits to Vishal for taking up this challenging project head-on!

The FASEB Lipid Droplet Conference is almost here! Check out the full agenda of great speakers: events.faseb.org/event/lipid-dr…

.Xiao Li, Gamuyao, CC_Lab et al. @stjuderesearch engineer a #LipidDroplet (LD)-targeting motif and develop a tool kit that can track contact sites between LDs and other organelles in living cells. hubs.la/Q02F1yfK0 Daniel Stabley Alex Carisey Alison Tebo

For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome. nature.com/articles/s4158…

.Sho Suzuki (he/him) et al. propose that Vps13 may play a critical role in supplying #lipids to #endosomes, ensuring continuous ESCRT-mediated sorting during MVB biogenesis. hubs.la/Q02D4gKl0 From our Inter-Organelle Contacts collection: hubs.la/Q02D4hdX0

After a gap of 4 years, the EMBO TB meeting returns, this time CCMB Hyderabad. Feb, 9-12, 2025 #Tuberculosis #heterogeneity #drugs #hostpathogeninteraction ICGEB, New Delhi Department of Biotechnology Amit Singhal Priscille Brodin meetings.embo.org/event/25-tuber…

#Lipid synthesis drives cell invasion. Kieop Park et al. Dave Sherwood lab Duke University reveal that invasive cells need a rapid lipid production system and a dynamic prenylation process to breach basement membranes. hubs.la/Q02GL9bK0

🚨Published eBioMedicine – The Lancet Discovery Science A new approach to study #Mtb physiology & #TB diagnosis. Our study uses #RNAscope to detect #Mycobacterium #tuberculosis mRNA in human tissue, even when traditional ZN staining fails. UAB Microbiology Africa Health Research Institute UAB Pathology thelancet.com/journals/ebiom…

PerturbAtlas: A Comprehensive Atlas of Public Genetic Perturbation Bulk RNA-seq Datasets biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

This "frugal CRISPR kit" costs about $2. It includes a cell-free extract (no living cells), plasmids encoding colorful proteins, and Cas9 + guide RNAs. Students express colorful proteins in the extract & then use CRISPR to cut the protein-coding genes, leading to loss of color.

Johnson et al. De Camilli Lab Yale Neuroscience show that the ER-anchored lipid transfer protein TMEM24/C2CD2L & its paralog C2CD2 mediate ER–plasma membrane junctions at cell–cell contacts by interacting w/ band 4.1 proteins & indirectly w/ cell adhesion proteins hubs.la/Q02LK29G0

Persons lacking TNF are healthy & fend off most infections, but are susceptible to tuberculosis w/ impaired macrophage respiratory burst nature Anna-Lena Neehus @AriasAAS Stephanie_Boisson-Dupuis Franco Casanova Lab Laurent Abel Bustamante Jacinta nature.com/articles/d4158… nature.com/articles/s4158…

A Comprehensive App to Interpret and Visualize the Functional Analysis of KEGG Pathways and Gene Ontologies biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

I've recently discovered a really useful R package by Jan Broder Engler called tidyheatmaps. It's designed to make creating heatmaps from tidy data easy, especially for publication-quality visuals. The package uses pheatmap for detailed heatmaps with less coding. If you work

What are 26 different Rab GTPases doing on Lipid Droplets? Are lipids transferred by membrane contact sites? Moving the FAT: Emerging roles of Rab GTPases in the regulation of lipid droplet contact sites by Mariano Alonso @albertpol10 and Harriet P Lo sciencedirect.com/science/articl…

📢Call for application: TATA Innovation Fellowship 2024-2025 A highly competitive scheme instituted by Department of Biotechnology, Ministry of Science & Technology, Govt. of India to recognize and reward scientists with outstanding track record in biological sciences/Biotechnology to find