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Multimodal chromatin profiling using nanobody-based single-cell CUT&Tag go.nature.com/3WvhLrO

I am really excited 🥳 that this work is now out in Nature Biotechnology What used to be sci-fi is now possible! Profile 3 epigenetic modalities with single-cell resolution using sc-nano-CUT&Tag.

I’ve made this video as an intuition pump for the density of #synapses in the #brain. This volume ~ grain of sand, has >3.2 million synapses (orange cubes). Peeling them away leaves only inputs on 2 #neurons. Zooming in, we see the synapses localized to the dendritic spines. #b3d

One of my favorite @nature covers for this week’s issue

If you’re interested in epigenetics, don’t miss this opportunity! Marek is a brilliant scientist working on cutting-edge research and is fun to work with!

PhD position(s) in our lab Karolinska Institutet! kidoktorand.varbi.com/en/what:job/jo…

Excited to announce that our multiomic atlas of early human brain neurodevelopment is now on biorXiv! Thank you to all contributors. Sten Linnarsson Lijuan Hu, Peter Lonnerberg, Marijn Schipper, @ReagorCaleb, Xiaofei Li, Roger Barker, Erik Sundstrom and Danielle biorxiv.org/content/10.110…

Thrilled to share our work: Glioblastoma is spatially organized by neurodevelopmental programs and a glial-like wound healing response. Led by J. Janusauskas and myself. biorxiv.org/content/10.110….

Glad to see that our paper is currently featured as one of the most-read papers in the #Bioinformatics journal

You can find the paper here - academic.oup.com/bioinformatics…

Another great Molneuro retreat! ...with Onur Dagliyan Sten Linnarsson Ulrika Marklund Per Uhlén Ernest Arenas Jens Hjerling Leffler ⭐️⭐️🇺🇦⬜️🟥⬜️ Patrik Ernfors' labs Karolinska Institutet!

bioRxiv by Emilia Síf Ásgrimsdottir et al. Midbrain Dopaminergic Neuron Development is Regulated by Two Molecularly Distinct Subtypes of Radial Glia Cells biorxiv.org/content/10.110… a great collaboration with Enrique M Toledo Gioele La Manno Sten Linnarsson

Petra Kukanja & Christoffer Langseth et al. tour-de-force it is now out in Cell Cell! An one-of-a-kind collaboration with MatsNilssonLab, powered by the fantastic in situ sequencing technology Mats pioneered! Check it out at sciencedirect.com/science/articl…

Dear SC community. Join us on tomorrow, 9am for Mukund Kabbe Mukund Kabbe talk on Single-nuclei histone modification profiling of the adult human CNS. Link on our new website singlecellclub.openscience.mcgill.ca The Neuro Stratton Lab David Langlais GonçaloCasteloBranco

Our latest preprint, Mukund Kabbe's single-cell epigenomics (scATAC & Nano-Cut&Tag) of the adult human central nervous system, finding developmental epigenetic memory at HOX clusters in adult oligodendroglia! Karolinska Institutet biorxiv.org/content/10.110…

Single-nuclei histone modification profiling of the adult human central nervous system unveils epigenetic memory of developmental programs biorxiv.org/cgi/content/sh… #bioRxiv

The new class of HHMI investigators average 3.9 papers as corresponding author in Cell, Nature, or Science. 26 out of 26 members of this group previously trained with a PI who is in the National Academy of Sciences or who was an HHMI investigator themselves.