Evaluation of non-invasive biomarkers of #kidney allograft rejection in a prospective multicenter unselected cohort study (EU-TRAIN) doi.org/10.1016/j.kint… Inserm Paris Transplant Group Université Paris Cité Assistance Publique – Hôpitaux de Paris (AP-HP) Charité - Universitätsmedizin Berlin Hôpital Necker AP-HP #OpenAccess #HLA #transplantation #transplant

Human #Kidney #KidneyFibrosis #SpatialTranscriptomics (Visium 11 case + 4 ctrl; CosMx 1 + 1) + sc-/sn-RNAseq (n=47) + snATACseq (n=18)▶️ Fibrotic microenvironment gene signature, instead of histologic fibrosis score, predicts renal function decline (eGFR), based on kidney tubule

1/17) We are thrilled to share our new paper published in @Jclinicalinvest (rb.gy/i2hwnn) that investigates the effect of the metalloproteinase #ADAMTS12 on perivascular fibroblast activation in #fibrosis led by me and Lars Koch

Antinephrin Autoantibody Podocytopathy from Tobias B. Huber #RKDSummit #Nephpearls 📌 Antinephrin Autoantibodies are associated with disease ☑️ 69% in active minimal change disease (MCD) pre-treatment ☑️ 90% in active idiopathic nephrotic syndrome pre-treatment 📌

Just came across this 🔝🔖 by Rijnink and cols A friendly reminder that not every Full-house nephropathy is #SLE and why it DOES matter #Nephpearls 👇🏿 academic.oup.com/ndt/article/32…

En lupus, agregar al inicio del tratamiento micofenolato de mofetilo 500mg cada 12hr, comparado a lo habitual, ↓61% el riesgo de recaídas severas y ↓89% el de desarrollar nefritis lúpica En ensayo clínico #ISNyoung JAMA Network Open 2024 10.1001/jamanetworkopen.2024.32131

Anti-slit antibodies define response to therapy and prognosis much better than histopathological lesion patterns even among patients with steroid-resistant nephrotic syndrome kidney-international.org/action/showPdf…

Look how much more important is to know if a patient is genetic or has anti-slit antibodies than if has MCD or FSGS at kidney biopsy. We have finally come to the era of autoimmune, genetic and adaptive podocytopathies. No more MCD or FSGS used as diagnosis!

Happy to share our new paper Nature Communications led by Konrad Hoeft Tore Bleckwehl Sikander Hayat. Label-free single-cell RNA multiplexing leveraging genetic variability. nature.com/articles/s4146… 🔥🔥👇👇 Tweetorial will follow

Happy to share our new pre-print, "NRBP1 and TSC22D proteins impact distal convoluted tubule physiology through modulation of the WNK pathway" biorxiv.org/content/10.110…

En enfermedad renal crónica G3b y con falla cardiaca de fracción eyección reducida, bisoprolol, comparado a carvedilol, se asoció a ↓24% el riesgo de un evento cardiovascular mayor CJASN 2025 doi.org/10.2215/CJN.00…

Anti-slit diaphragm antibodies in autoimmune podocytopathy: •Anti-nephrin → frequent in kids •Anti-podocin → in kids & adults •Anti-Kirrel1 → more rare •Some patients have multiple autoantibodies. journals.lww.com/jasn/citation/…

Happy to share our first invited review in Current Opinion in Nephrology & Hypertension 🤓 We discuss the latest evidence on molecular and physiological effects of #flozins during #AKI repair and #fibrosis 👇🏿 journals.lww.com/co-nephrolhype…

Day 50 of #WhyScience 🤪🎇 Thrilled to share the preprint from one of my most talented trainees, Jon Levinsohn: "Single-Cell Spatial Mapping of Human Kidney Development Reveals the Critical Role of the Local Microenvironment in Cell Fate Decisions" Jon built a comprehensive

Reprogramación Tubular Patológica. Excelente seminario de Mike Martínez Rojas 🫘

Último día de nuestro mes en áreas críticas con el #DreamTeam de agosto 2025. Un mes de mucho aprendizaje 🚑, as we speak… Brenda Delgado Denisse Pérez Benjamín García Mike Martínez Rojas

Estudio fase 2 Baxdrostat (🚫aldosterona sintasa) en HTA descontrolada en ERC. Baxdrostat ⬇️15.2mmHg TA sistólica (⬇️-8.1 vs pbo) en gpo combinado de dosis baja o alta. ⬇️ 57.9% de albuminuria (-55% vs pbo). shorturl.at/rmxFG Fase 3 (BaxDuo Pacific) ya reclutando en México!

Científicos de fisiología molecular del INNSZ publican una revisión sobre el efecto que pudieran tener los iSGLT2 en la transición de lesión renal aguda a crónica. Curr Opin Nephrol Hypertens 2025 10.1097MNH.0000000000001080

🚨 Kidney + AI milestone 🚨 Never been more excited to share!!! We built Nephrobase Cell+, the first multispecies, multimodal kidney foundation model: Trained on ~40M cells Across 4 species (human, mouse, rat, pig) From 5 modalities (scRNA, snRNA, snATAC, CosMx, Xenium) Kidney

En el encuentro nacional de investigadores premios: - Mejor trabajo de investigación básica: Norma Bobadilla - Mejor artículo básico en 2024: Norma Bobadilla - Mejor tesis doctoral de 2024: a Mike Martínez Rojas alumno de Norma Bobadilla. Nefrología rules!! INCMNSZ Departamento de Nefrología y Metabolismo Mineral