Have you ever wondered what bacteria dream of as they sleep? Do you like quantitative approaches to single cell behavior? Time-lapse microscopy and microfluidics? Like to analyze your own data? Come join our lab!

📢 How can we identify cell lineages from any scRNA-seq dataset ? Check our paper: nature.com/articles/s4146…. Very proud of massive amount of beautiful work by Almut Eisele, A. Dormann + fantastic collaboration with @MTarbier and Pelechano lab. A 🧵

Big congratulations to all laureates 🥳and amazing news for IGBMC with two winners 🤩

Psst! An updated version of our paper is up biorxiv.org/content/10.110… 🤫We added perturbation of the ATAC coactivator, and we still find RNA buffering! Thanks to all who commented on the original version and🤞as we wait for journal peer reviews

Thrilled to share the culmination of 4 years of #Fiberseq research enabling the accurate quantification of chromatin accessibility across the 6 Gbp diploid human genome with single-molecule and single-nucleotide precision. See thread for the main findings biorxiv.org/content/10.110…

Come do your postdoc in beautiful Strasbourg IGBMC! Collaborative project in #RNA biology between our lab and Nacho Molina 🇪🇺. Details below, please RT!

Deep learning advancements change how we address challenges & bottlenecks in #SingleCell biology. See how researchers are transforming what's possible using existing data to understand health + disease with cutting edge computational approaches bit.ly/3y7EB1X

I am very happy that CZI Science has selected our research project!

Indeed, looking forward to this collaboration with you Nacho Molina 🇪🇺! EPFL Life Sciences CZI Science

A heads up to all post-docs - the Genome Biology dept @EMBL is recruiting - independent group leader (PI) position. Outstanding colleagues, students, world-leading core facilities in a very supportive, collaborative and family environment, #jobs. Ad will be posted in next days

Hey, interested in discovering the molecular mechanisms behind our puzzling observations on gene-specific RNA buffering? We need you. Apply now! 👇#PostdocPosition #RNAbiology #scRNAseq Manuel Mendoza longchrom.bsky.social Nacho Molina 🇪🇺

Excited to share the latest story from the @arnaud_kr lab EMBL ! Together with Christine Moene we used Single Molecule Footprinting to reveal that RNA Pol II occupancy occurs at surprisingly low-frequency at mammalian promoters! Thread below (⬇️) 1/11

After a massive team effort leaded by the incomparable Nicola Festuccia I am really happy to share our freshly published Science Magazine ms where we elevate Nr5a2 to the top of gene regulation in the morula. 🔥🔥🔥 Take a look at Nicola's description 👇! science.org/doi/10.1126/sc…

Happy to see published on CDD press the result of an Fondazione AIRC per la ricerca sul cancro funded study, coordinated with the tireless Alessandra Agresti and led by Federica Colombo on the role of NF-κB in multiple myeloma (MM), and its interaction with stromal cells (MSCs) nature.com/articles/s4141…🧵

🚨 New method alert! We developed HiddenFoot, a physics-inspired approach to decode single-molecule footprinting data and infer TF, nucleosome, and RNA Pol II binding profiles on individual DNA molecules. One molecule at a time! biorxiv.org/content/10.110…

Just in case you missed this and it’s something that might interest you. #SingleMoleculeBiology, #Chromatin, #Transcription, #TF, #Nucleosome, #PolII, #Biophysics, #MachineLearning, #ComputationalBiology 👇

Carrying on with Session 4 on #EMBLSingleMolecule Day 3 🤓💪🏼 ➡️ 'Decoding Gene Regulation at the Single-Molecule Level through Biophysical Modeling of DNA Footprinting Data' 🎙️ Nacho Molina – Institute of Genetics and Molecular and Cellular Biology, France