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Rules of academia: Questions are more important than facts Answers are temporary Models are provisional Failure happens a lot Patience is a requirement When you’re lucky, hopefully you realize it Things don’t unfold linearly If there’s free food, get there early —Stuart Firestein

Late breaking at #ASCO23: Mutations in isocitrate dehydrogenase 1 or 2 are common in low-grade glioma. The IDH inhibitor vorasidenib improved progression-free survival as compared with placebo. Full results of the INDIGO trial: nej.md/3N8N5dU

Congratulations to Lucie Wolf from the Angers Lab! 🎉 Lucie is our 2023 Charles H. Best Fellow. The #fellowship will support her research on finding new regulators of the Wnt signalling pathway, with potential for targeting #cancer cells. Learn more 👉 bit.ly/2023BestFellow

Knowledge is good, even if it is not immediately actionable.

To the many PhD students starting this month: choosing a mentoring lab - which is THE crucial decision - should be made based on the atmosphere in the lab, the attention you will get from the mentor, what they can teach you, funding, and the lab’s topic, probably in that order.

CRISPR reprograms cancer cells into healthy muscle tissue in the lab! Researchers disable a specific protein in rare skeletal muscle cancer cells, turning them into normal muscle cells. livescience.com/health/cancer/…

Thrilled to share our recent work published in Development from my PhD at Angers Lab. This research introduces a novel approach by using Wnt receptor antibodies to understand neural patterning and enhance the differentiation of hPSCs into DA neurons.📰🧵journals.biologists.com/dev/article/15…

Researchers at University of Toronto have found a new method to treat the symptoms of #Parkinsons disease. By selectively activating a key signaling pathway, they were able to direct stem cells in the midbrain to develop into neurons. Learn more 👉 uoft.me/Neurogenesis

Tonight, my thoughts are with the countless victims of the Islamic Republic – those whose lives were taken due to the crimes of Ali Khamenei and Ebrahim Raisi. Their futures were stolen and many endured untold suffering in their final moments. We will always remember our heroes.

It's a beautiful day at Niagara-on-the-Lake! 🌞 Donnelly Centre faculty, trainees and staff are at Queen's Landing Hotel for our annual retreat. #DonnellyRetreat2024 #UofT

1/🚀Excited to share our latest work on sciRED, a new computational method for enhancing factor identification and interpretation in scRNA-seq data. sciRED extracts factors from gene expression data, and uses ML approaches to identify known covariates and novel factors.

6/🔗 Read our full manuscript to dive deeper into sciRED's capabilities and our findings: biorxiv.org/cgi/content/sh… Gary Bader Tallulah Andrews

Join us at the Donnelly Centre for our next Donnelly #Seminar Series speaker: Federico Gaiti from Temerty Medicine and University Health Network! 📅 Thursday, October 17 at 11am ET 📍 Red Seminar Room at Donnelly Centre | Zoom Save Your Spot 👉 uoft.me/FedericoGaiti

Very cool to be featured in 'Humans of RHSE'! RHSE_UofT Donnelly Centre Stephane Angers Read more about my postdoctoral work and beyond here: rhse.temertymedicine.utoronto.ca/news/humans-rh…

A team led by University of Toronto researchers has uncovered new targets that could be key to effectively treating #glioblastoma, a lethal type of brain #cancer. Glioblastoma is challenging to treat due to the resistance of its stem cells to therapy. Learn more 👉 uoft.me/Glioblastoma

🎉 Excited to share our latest work in StemCellReports! This marks the final chapter of my postdoc in the Angers Lab. cell.com/stem-cell-repo… 🧬✨ We show how individual Frizzled receptors regulate Wnt-β-catenin signaling kinetics in hPSCs, influencing mesoderm commitment🧵1/n

Excited to share that our paper on identifcation of Injury-Response state determinants in glioblastoma stem cells is now available on bioRxiv. Graham MacLeod, PhD Angers Lab Link to the manuscript biorxiv.org/content/10.110…

🧵1/ Excited to share our new preprint: FLASH-MM - a fast and scalable method for single-cell differential expression using linear mixed models, enabling DE analysis in massive scRNA-seq datasets. 🔗doi.org/10.1101/2025.0… #Changjiang_Xu Veronique Hamed Heydari Gary Bader

Amazing news! 🌟 Baby KJ received a custom CRISPR therapy for a life-threatening genetic disorder, developed in a record 6 months! He's now thriving, and this breakthrough could revolutionize personalized medicine. A true game-changer! 🧬 #CRISPR wired.com/story/a-baby-r…