Now in PNASNews~ Congrats, Hyemin Seo , krishnamohan, Aarthi Putarjunan, former NaturalSciences @ UT undergrad Lyndsey Aguirre @futuredrscience & former UW Biology undergrad, Ben Burrows! SCREAM ACT-like domain as a bHLH partner selectivity interface 🌱 pnas.org/content/119/9/…

Our latest! OA from Nature Plants 🌱🔬🧬 We report a lexicon of dynamic chromatin accessibility through stomatal development. This revealed the key regulatory point at the proliferation-differentiation switch 1/ nature.com/articles/s4147…

Our genetic/molecular/biochemical/biophysical anslyses showed that BPC1/2 repress SPCH and stomatal precursor proliferative stage, but how? We found that BPC1/2 physically associate with MUTE but not SPCH. 3/

Long-Range Coupled Motions Underlie Ligand Recognition by a Chemokine Receptor cell.com/iscience/fullt…

Foreign born CEOs of American companies: 🇮🇳 Alphabet Google 🇮🇳 Adobe 🇲🇾 Broadcom 🇬🇧 Coca-Cola 🇮🇳 IBM 🇫🇷 Instacart 🇮🇳 Honeywell 🇪🇸 Johnson & Johnson 🇵🇰 KFC 🇩🇪 Mastercard 🇮🇳 Micron Technology 🇮🇳 Microsoft 🇹🇼 Nvidia 🇮🇱 Oracle 🇪🇸 PepsiCo 🇬🇷 Pfizer 🇮🇳 Starbucks 🇮🇪 Stripe 🇿🇦 Tesla,

Chandrayaan-3 Mission: 'India🇮🇳, I reached my destination and you too!' : Chandrayaan-3 Chandrayaan-3 has successfully soft-landed on the moon 🌖!. Congratulations, India🇮🇳! #Chandrayaan_3 #Ch3

The moment when India reached on the Moon. #Chandrayaan3 #Chandrayaan3Landing #Chandrayaan_3

Chemical inhibition of stomatal differentiation by perturbation of the master-regulatory bHLH heterodimer via an ACT-Like domain biorxiv.org/content/10.110…

新作です! 植物のbHLH指令転写因子の二量体形成を阻害することにより気孔の幹細胞を停止させる化合物を創出。植物bHLH特有の機能未知なACTLドメインに結合。構造予測から薬剤耐性植物の作出にも成功。名古屋大ITbMの合成化学の専門家との共同研究 x.com/Stomata_Tweets… biorxiv.org/content/10.110…

Chemical genetics reveals cross-activation of plant developmental signaling by the immune peptide-receptor pathway biorxiv.org/content/10.110…

Congrats all! We found a new bioactive molecule, Stomidazolone, from our methodology-based chemical library. Nature Communications I sincerely appreciate Prof. Torii Prof. Keiko Torii and her group members. This beautiful figure was prepared by Prof. Takahashi. nature.com/articles/s4146…

気孔を減らす化合物創出の論文が⁦Nature Communications⁩ に掲載されました。気孔の司令転写因子MUTEに結合し、SCREAMとのヘテロ二量体形成を阻害。構造モデルから化合物耐性植物も作出🪴。合成化学の村上先生⁦Murakami Lab⁩ との共同研究です。共著者の皆様おめでとう🥰 nature.com/articles/s4146…

気孔の司令因子は、神経や筋肉分化の司令因子同様bHLH型ですが、C末端にACT様領域がついた植物特有のもの。今回報告した化合物Stomidazoloneは、ACT様領域に結合する、初の二量体阻害剤です。化学の視点では、三次元骨格をもつイミダゾロン化合物を１工程で合成する新規手法の確立に成功⚗️🧬 2/

Just published🌱⚗️! Discovery of Stomidazolone, a new compound reducing the numbers of stomata by binding to the MUTE ACTL domain and perturbing the MUTE-SCRM heterodimerization. Fantastic collaboration w/ Organic Chemists Murakami Lab. Congrats, all! nature.com/articles/s4146…

研究ハイライト 植物の気孔を減らす化合物の合成に成功　 ～気孔発生司令因子の機能を妨害する化合物の発見～ itbm.nagoya-u.ac.jp/ja/research/20…

これはオキサゾールのC-Hアミド化を狙っていた時に発見した”不思議反応”から始まりました。Yip博士が予想もしない副生成物を単離しました。そして、その化合物の新たな活性を鳥居先生Prof. Keiko Torii、中川先生とHan先生に見つけもらいました。二つの偶然に導かれ、多くの人の協力で形になりました。

‘Never seen anything like this’: Trump’s team halts NIH meetings and travel nature.com/articles/d4158…

New research finds the activation of immune signaling can cross-regulate the otherwise highly specific stomatal development signaling if the availability of the shared downstream components becomes suboptimal. Learn more in this week’s issue: scim.ag/3WPx6pv

Our latest made to the cover Science Advances! The power of chemistry unveiled the signal specificity boundary bet/w development & immunity. Congrats, Arvid, Krishna krishnamohan , Pengfei, all the collaborators, esp. Itami Lab 🥳⚗️🌱. science.org/doi/10.1126/sc…

Chemical genetics reveals cross-regulation of plant developmental signaling by the immune peptide-receptor pathway | Science Advances science.org/doi/10.1126/sc…