America has some secret weapons that make this country great in science. They are called the H1B and J1. They allow the best and brightest from all over the world to come here to work, learn, innovate, and advance knowledge for the benefit of everyone.

Nintendinitis | NEJM A classic ⁦⁦NEJM⁩ letter from the late Dr. Richard Brasington, a rheumatologist who coined the term: “Nintendinitis” Rick passed away this year, & one of his sons (mentioned in this letter) passed away just months later. nejm.org/doi/full/10.10…

Groundbreaking update from the world of rare disease research! As many of you know, I’ve been building a team and supporting research to better understand and treat RVCL, the rare genetic condition that took my mom at the young age of 50. In the 19 years that I have been

Our laboratory is hiring at the Postdoc or RA level! If Innate Immunology and Autoinflammatory Disease are of interest to you consider to join us Hudson Institute in Melbourne Australia! seek.com.au/job/77002348 seek.com.au/job/77007854

Researchers Identify Underlying Disease Mechanism in RVCL bit.ly/4cOoyoG #RVCL #RetinalVasculopathyWithCerebralLeukodystrophy #Leukodystrophy #CerebralLeukodystrophy Alex, The Leukodystrophy Charity

I am both delighted and honored to share the fruit of a wonderful thinking and writing exercise with CrowLab. Injecting some human genetics (literally) and endocrinology (figuratively) into immunology might be refreshing 🙂 science.org/doi/10.1126/sc…

Our new study on IL-12 regulation of Tfr cell biology is out at Science Immunology. This one is for #cytokineaficionados. International Cytokine & Interferon Society (ICIS) Penn Microbiology

Colonna and colleagues provide a resource of ILC1 heterogeneity in human tissues. Read it here: rdcu.be/dM64F nature.com/articles/s4159…

Trust nothing. Validate everything. nature.com/articles/d4158…

Congrats to the now Dr. Ruchi Patel for the publication of her PhD thesis in Science Immunology. We show here that CD5 deletion enhances CART immunotherapy in multiple solid and liquid cancer models. Penn Medicine Ruella Lab science.org/doi/10.1126/sc…

I’m excited to be back on the University of Michigan (University of Michigan) campus to meet with the RVCL research team and receive formal updates on their progress. Four years ago, we established a grant with UM through The Clayco Foundation to begin a custom drug development effort for RVCL,

We (and our mice) are working on it.

Thrilled to have our annual CAMB Graduate Group Microbiology, Virology, & Parasitology (MVP) retreat! Fantastic talks & posters by junior faculty & students, along with science-themed Family Feud! We even got to sing Happy Birthday to ChrisHunter! Thanks everyone for a great day!

What’s special about September 30th? It’s the day we will choose our top candidate compound for subsequent toxicology—and hopefully this leads to our first Phase I trial of a personalized TREX1-targeted drug to treat RVCL.

These are fruitfly eyes from our collaborators at the Brain Research Institute in Niigata, Japan. The lower image is a fruitfly with a truncated human TREX1 gene that causes RVCL. We discovered that RVCL is DNA damage syndrome associated with early-onset breast cancer in women.

UMass Chan Medical School seeks the next generation of scientific leaders! Join our research community as a UMass Chan Early Independence Fellow. Get 3-5 years of support. Apply by Dec 1: academicjobsonline.org/ajo/jobs/28425 UMass Chan Medical School RNA Therapeutics Institute

Congratulations to Zhijian “James” Chen, 2024 #LaskerAward winner! – “for the discovery of the cGAS enzyme that senses foreign and self DNA, solving the mystery of how DNA stimulates immune and inflammatory responses.” laskerfoundation.org/winners/cgas-e… #Lasker2024 #LaskerLaureate

So well deserved! #Lasker award for the discovery of #cGAS to James Chen. So much more to learn about cGAS in cancer, infectious diseases ... and beyond. Also a major target to treat diseases.

"Sensing DNA as danger: The discovery of cGAS" by Richard Flavell and Esen Sefik discusses the importance of #LaskerAward winner Zhijian "James" Chen's work. UT Southwestern Medical Center Immunity cell.com/immunity/abstr…

How can we teach high school students in any geography about the power and magic of CRISPR gene editing? Sarafan ChEM-H Institute Scholar Stanley Qi Lab and affiliate Michael C. Jewett Stanford Engineering developed this affordable kit! nature.com/articles/s4146…