Excited for SFBiomaterials! Mimi Guo will present on biomaterial platforms to study hypertrophic cardiomyopathy (Thur 3p, talk # 238) and Daniel Simmons will present on controlling engineered heart muscle shape to control electrophysiology (Sat 11:15a, talk #356)

Congratulations and a crisp high five to Nate Huebsch and Bérénice Charrez for their brilliance and determination in pushing through their new paper on hiPSC-CM maturation in a 3D microphysiological system. Nature Biomedical Engineering Berkeley Engineering Berkeley Bioengineer Berkeley MSE #MPS #OrganChips

We have an immediate opening for a postdoc in cardiac mechanobiology and biomaterials. Please send me a note at [email protected] if interested.

New preprint from Daniel Simmons in our lab. Our team developed a simple method to replicate high resolution 3D prints into into PDMS, and used this to study how tissue shape controls electrophysiology of human iPSC-derived micro-heart muscle. biorxiv.org/content/10.110…

Heading to San Antonio for BMES to share a couple of our latest projects in cardiac tissue engineering to study inherited diseases.

We have openings for a Staff Scientist (JR70425) and Postdoc (JR70913), please look on jobs.wustl.edu and apply if you are interested in joining our team to leverage biomaterials to study the mechanobiology of genetic heart disease.

Congratulations, Dr. Simmons.

Thrilled to be able to share this collaboration with Guy Genin led by Louis Woodhams and Jingxuan Guo! For those interested in trying virtual blebbistatin on your videos, you can find the package here: doi.org/10.5281/zenodo….

Such a tremendous honor. Thank you to my mentors both before and at WashU, along with wonderful members of the team here. Special thanks to my mentors as a trainee, k healy, Dave Mooney Wyss Institute, Bruce Conklin Gladstone Institutes and many others.

Excited to post our work, just accepted in iScience. Led by Jingxuan Guo, our team used biomaterials to control the mechanical load that iPSC-derived heart muscles work against. Both mechanical load and 3D tissue environment proved essential to observe hypertrophy linked to

hypertrophic cardiomyopathy (Myosin Binding Protein C mutation) and associated defects in myofilament structure and calcium handling. cell.com/iscience/fullt…. Congrats to Mimi and the rest of the team!

Interested to learn how to use iPSC platform and simple biomaterials to capture early Hypertrophic Cardiomyopathy and investigate disease mechanisms? Check out the latest iScience paper by the Huebsch lab!

How does heart tissue react to stress? In the recent study led by Jingxuan Guo, Nate Huebsch Lab, iPSC-derived heart tissues reveal how different levels of stiffness can trigger structural and functional issues in hypertrophic cardiomyopathy. Read more here doi.org/10.1016/j.isci…