Me: oh it’s fine experiments fail all the time. Also me: WHO TOOK THE ICE SCOOP I WILL FIGHT YOU #phdchat

We are proud to announce that we found who removed the debris of dead microglia. In a word, non-professional phagocytes phagocytose the debris of professional phagocytes in the central nervous system. nature.com/articles/s4146…

Accomplishment unlocked: triggered a brand new Matlab bug during imaging where buttons just straight up disappeared in the middle of a session 🫠

Have you ever wished to sequence SPECIFIC bacteria but NOT the vast background in #microbiome? Today, we introduce *mEnrich-seq*: #methylation-guided enrichment sequencing of bacterial taxa of interest from microbiome. 4yr project led by Annabel Cao! biorxiv.org/content/10.110…🧵1/10

I just microwaved my matcha latte and it feels sacrilegious

Hunger and mouse surgery don’t go well together at all. Suture practice was such a struggle… I now have a brand new level of respect for surgeons 🧐

Found out that I’m not a jeopardy type of person today in class. My brain refused to synthesize the concepts into actual words so I blanked out on action potentials and EPSPs 😃

In case anyone is interested, I also have ggtraces, a ggplot compatible tool for visualizing line traces (e.g., chromatograms), which aligns line graphs along a parallelogram. A key feature is adjustable perspectives between side view & top view. GitHub: github.com/cxli233/ggtrac…

Go Surjeet!!!

Bacteria that use histones to organize their chromatin. There. I said it. biorxiv.org/content/10.110…

Yayyyyy congrats!!! 🍾🎉🎊

New paper! Brianna Gurdon and Sharon Yates expand QUINT workflow for nonlinear refinement of brain atlas-registration and QC for quantifying cell and pathology changes in diverse mouse populations (eg AD-BXDs) that better model humans, and ID genes correlated w/ cell load & age!

👇🎉 Delighted to finally share this👇 nature.com/articles/s4159… "Contextual guidance": what if we started thinking of astrocytes as contextual gates whose core function is to shape neural circuitry in a state-dependent and adaptive fashion?

As promised: STARDUST2.0 with code release, for those looking to capture regional calcium dynamics in astrocytes. Amazing work from Yifan Wu and Miko Dai biorxiv.org/content/10.110…

How a crying baby is similar to denoising an ephys rig: 1) There's noise and you don't know why 2) You need to stay grounded 3) You have superstitious beliefs about what actions stop the noise 4) These actions work sometimes but not always 5) The noise can randomly start again