Come check out our amazing 😁 paper on lipid droplet biogenesis by the yeast Seipin complex out now in Nature Communications! It was fantastic to work on this project with Susan Lea @pstansfeld Justin Deme Robin Corey @robincorey.bsky.social Mike Renne and twitterless Pedro Carvalho. nature.com/articles/s4146…

Latest review from the Carvalho Lab is out in CSH Perspectives, showcasing the exquisite complexity and versatility of ERAD and the essential roles E3 ligase complexes play in this process. Get it while it's hot! Loges Krshnan Dunn_School (now @DunnSchool.bsky.social) cshperspectives.cshlp.org/cgi/content/lo…

New preprint out now from the Carvalho Lab! In this exciting story, postdoc Zhe Ji zhe and graduate student Wingyan Skyla Siu Wingyan Skyla Siu identify CTDNEP1-NEP1R1 as the elusive R-SMAD phosphatase that terminates TGF-β signaling! biorxiv.org/content/10.110…

Just out from the Carvalho lab!!! Yours truly, Nik Sergejevs and colleagues together with LuLin Jiang and Matthias Trost 🇪🇺 discover a new role for the RNF185-Membralin ERAD complex in regulating Tapasin assembly with the PLC! Get it while it's hot! nature.com/articles/s4146…

Ever wondered how fat is stored in the cell? Well, it's stored in lipid droplets, but how are they formed? Our understanding of this process is nicely reviewed here by Pedro Carvalho and Robin Klemm annualreviews.org/content/journa…

Excited to share my first, first-author manuscript on the role of Signal Peptide Peptidase in membrane protein quality control. Massive thanks to our collaborators, @Marius_Lemberg Dönem Avci Robin Corey @robincorey.bsky.social and postdoc Michael van de Weijer Dunn_School (now @DunnSchool.bsky.social) journals.biologists.com/jcs/article/do…

And it's out! Some nice biochemistry reveals how the yeast Seipin compelx organizes in vivo across LD formation biorxiv.org/content/10.110…

Hot off the press! A new study by the Carvalho lab reveals a novel role of the CTDNEP1 phosphatase together with MAN1 in suppressing TGF-β/SMAD signaling! nature.com/articles/s4146…

Excited to share the new work from the Carvalho lab Dunn_School (now @DunnSchool.bsky.social)! 🎉This was part of my PhD & a collaboration with the VanniLab & Ernst labs! Big thanks to everyone involved! 🙌 Read more: doi.org/10.1083/jcb.20… (1/2)

Our latest review on the transmembrane domain recognition during protein quality control is now available! Enjoy the read: sciencedirect.com/science/articl…