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Excited to share my group's first pre-print from the MRC WIMM. We screened ~7000 genes for their roles in blood stem cell differentiation in vivo: biorxiv.org/content/10.110… We also made a webapp resource so you can search for your favourite genes: hematopoiesiscrisprscreens.com 1/3

B12 deficiency can affect every part of the nervous system. But what if B12 levels in the blood do not reflect those in the brain? Check out our preprint on “Transcobalamin Receptor Autoantibodies in Central Vitamin B12 Deficiency”: medrxiv.org/content/10.110…

I’m thrilled to see @ia_windham and team’s work about the trafficking of #APOE to #LipidDroplets published today in Journal of Cell Biology: rupress.org/jcb/article-ab… ApoE Discoveries

What Alzheimer noted as fat saccules in glia may have been lipid droplets. They can be induced by Abeta in microglia leading them to release factors that damage neurons. ApoE4 makes things worse rdcu.be/dA6Kh. Congrats Michael Haney Robert Palovics and fantastic team