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Great to see our finding of heteromeric amyloid filaments of TDP-43 and annexin A11 in FTLD-TDP Type C now online nature! nature.com/articles/s4158…

Red light, green light: flickering fluorophores reveal biochemistry in cells nature.com/articles/d4158…

And we’re off! Don’t forget to tag us in your amazing work during the conference #isftd2024

Development of a cell-permeable Biotin-HaloTag ligand to explore functional differences between protein variants across cellular generations | bioRxiv biorxiv.org/content/10.110…

Grateful to the Kissick Family Foundation and Milken Institute for this joint award with Len Petrucelli to study the molecular origins of FTD milkeninstitute.org/content-hub/ne…

Pervasive mislocalization of pathogenic coding variants underlying human disorders: Cell cell.com/cell/abstract/…

Our take on striking new findings from the Ryskeldi-Falcon lab on hybrid protein filaments in disease. I suspect this will be the tip of the iceberg, and there are additional implications for normal cell biology from their study. nature.com/articles/d4158…

Our paper on cryptic splicing-controlled protein expression, which we hope will inspire safer and more adventurous gene therapy approaches for ALS and FTD, has been published in Science Magazine science.org/doi/10.1126/sc…

So cool! ExoSloNano: Multi-Modal Nanogold Tags for identi-fication of Macromolecules in Live Cells & Cryo-Electron Tomograms | bioRxivso biorxiv.org/content/10.110…

An ANXA11 P93S variant dysregulates TDP‐43 and causes corticobasal syndrome - Snyder - 2024 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associated Disease as a Lysosomal Disorder | bioRxiv biorxiv.org/content/10.110…

PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes - ScienceDirect sciencedirect.com/science/articl…

Machine-guided design of cell-type-targeting cis-regulatory elements | Nature nature.com/articles/s4158…

Arc mediates intercellular tau transmission via extracellular vesicles | bioRxiv biorxiv.org/content/10.110…

A substantial reduction of #Alzheimers disease associated with semaglutide (Ozempic) in > 1 million people with Type 2 diabetes from a nationwide data resource alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2

Preprint alert! Led by Shannon Rhoads, we used 🌈🔬 to elucidate the #organelle signatures of #neurons and #astrocytes at baseline and in response to neurodegenerative-disease associated stressors. See Shannon's awesome tweetorial below! biorxiv.org/content/10.110…

Heterogeneity of late endosome/lysosomes shown by multiplexed DNA-PAINT imaging | Journal of Cell Biology | Rockefeller University Press rupress.org/jcb/article/22…