Publication by the @MartinJinek, Giulia Palermo, Allain labs & Caribou Biosciences w/ first author Martin Pacesa "Structural basis for #Cas9 off-target activity" in Cell bit.ly/3FE2yzf #CRISPR #Crystallography #Structure #DNA University of Zurich UZH Science D-BIOL @ ETH Zurich ETH Zurich

Crazy cool to share our story on the type V CRISPR-associated transposon complex presented at #CRISPR2022. An amazing journey with my dear colleague and friend MichaelSchmitz, the fantastic Seraina Oberli and Christelle Chanez and the legendary @MartinJinek cell.com/cell/fulltext/…

Today in Nature Biotechnology, we describe HELIX, which harnesses nicking homing endonucleases to turn any type V-K CRISPR-associated transposase (CAST) into a high purity & high specificity multi-kilobase DNA insertion technology. 🧬 MIT Dept of BE @MGH_RI nature.com/articles/s4158…

Great to read this splendid nature news and views article by Barabas group and Phoebe Rice about our recent work in the @MartinJinek lab and the latest research in the group of Liz Kellogg ❄️🔬! MichaelSchmitz Seraina Oberli Christelle Chanez

🎙️Excited to launch my new podcast #CRISPRli, a deep dive into the revolutionary world of #CRISPR. I'll be hosting interviews with top genome editing experts. Ideal for scientists, students or anyone curious about this cutting-edge tech. #GeneEditing open.spotify.com/show/1NDD79fy2…

In the first episode, MichaelSchmitz talks about a recent study from the Jinek Lab University of Zurich on CRISPR-associated transposons. Learn how a host cell's ribosomal subunit kept the team awake at night and why structural biology is more relevant than ever in the age of #alphafold.

Watch our interview with group leader Irma Querques who recently joined the Perutz from University of Zurich. She talks about her research on transposons 🧬, what science has to do with a good TV series 📺 and more! ➡️tinyurl.com/3jf7xc5d Universität Wien

🚨 Today, we’re thrilled to share our study expanding the gene editing toolbox to enable virtually any kind of edit in gene transcripts at the order of thousands of bases. A thread 🧵👇(1/n) biorxiv.org/content/10.110…

Interested in genome editing? Don't miss our second in-person meeting 'CRISPR-Cas & Innovation in Genome Editing', organised with IAB ! 📍Grenoble, 30 November Preliminary programme & registration: docs.google.com/forms/d/e/1FAI…

🛠️Keen to explore transposon-based tools for site-specific gene integration? ➡️DNA on the move: mechanisms, functions & applications of transposable elements 🔓buff.ly/3RF0nRG 🖊️MichaelSchmitz Irma Querques #TransposableElements #CRISPR #GenomeEngineering #Transposons

🛠️New Review in the January Issue ➡️DNA on the move: mechanisms, functions & applications of transposable elements 🔓buff.ly/3RF0nRG 🖊️MichaelSchmitz Irma Querques #TransposableElements #CRISPR #GenomeEditing #PrecisionMedicine

New paper from our lab Nature Communications! Aakash Saha and colleagues reveal the dynamics and mechanism of target DNA traversal in #CRISPR-Cas12a, a conundrum in the field! nature.com/articles/s4146… #compchem We thank the amazing #HPC resources PSC (#Anton2) and San Diego Supercomputer Center

CRISPR gene editing has the potential to solve many problems in research, agriculture, and medicine. For the special 50th anniversary issue of Cell, we discuss its past, present and future directions with @MartinJinek and Oana Pelea. sciencedirect.com/science/articl…

Today in nature we present the results of our exploration of the soluble protein universe and the design of functional soluble membrane proteins with Casper Goverde Nico Goldbach Bruno Correia 1/6 nature.com/articles/s4158…

Check out our latest paper showing that HLTF removes Cas9 from DNA, explaining phenotypic differences when using the two Cas9 nickase variants. Important for gene editing! Thanks to Giordano Reginato & Rosaria and @MartinJinek Taekjip Ha andre nussenzweig lab nature.com/articles/s4146…