Michelle Xu (@mich__xu) 's Twitter Profile
Michelle Xu

@mich__xu

Phd Candidate @VictorChangInst studying drug-induced arrhythmias 👩🏻‍🔬🫀🔬 Pets I currently own and look after: one dog 🐕 and many stem cells 🧫

ID: 1445608215945748487

calendar_today06-10-2021 04:37:26

19 Tweet

54 Followers

77 Following

St Vincent's Campus Research Symposium (@svcrsymposium) 's Twitter Profile Photo

We will soon be moving on to twitter presentations! Our first ever twitter presentation will be coming online at 1 pm!! We are excited to bring this format to the St Vincent's Campus Research Symposium and look forward to seeing how our presenters utilize this format! #SVCRS2021 #MedicalResearch

Michelle Xu (@mich__xu) 's Twitter Profile Photo

Did you know that common drugs such as antihistamines can induce abnormal heart rhythms, with some of them even causing sudden death? 😱 This phenomenon is known as drug-induced long QT syndrome and arises due to disturbances of electrical activity in the heart.🫀 #SVCRS2021 1/5

Did you know that common drugs such as antihistamines can induce abnormal heart rhythms, with some of them even causing sudden death? 😱
This phenomenon is known as drug-induced long QT syndrome and arises due to disturbances of electrical activity in the heart.🫀

#SVCRS2021
1/5
Victor Chang Cardiac Research Institute (@victorchanginst) 's Twitter Profile Photo

#SVCRS2021 presenter Michelle Xu Michelle Xu: 'Diverse genetic background of individuals contributes to variable response to proarrhythmic drugs.' #HeartResearch #diLQTS #hERG #cardiomyocytes #CardioTwitter St Vincent's Campus Research Symposium #WomeninSTEM #WomenInScience

Michelle Xu (@mich__xu) 's Twitter Profile Photo

We measured electrophysiological responses to drugs in human #iPSC #cardiomyocytes from multiple patients to understand the extent of genetic variability and #proarrhythmic risk between individuals. This video shows a monolayer of beating cells and its response. #SVCRS2021 2/5

Michelle Xu (@mich__xu) 's Twitter Profile Photo

In most cases, the molecular basis of these side effects is due to block of #hERG potassium channels, which can lead to prolongation of cardiac #repolarisation and #arrhythmias. An individual’s response to a drug can differ depending on their expression of hERG. #SVCRS2021 3/5

In most cases, the molecular basis of these side effects is due to block of #hERG potassium channels, which can lead to prolongation of cardiac #repolarisation and #arrhythmias. An individual’s response to a drug can differ depending on their expression of hERG.

#SVCRS2021 
3/5
Michelle Xu (@mich__xu) 's Twitter Profile Photo

Moreover, some drugs can block multiple types of channels, meaning there is a complex balance between pro- and anti- #arrhythmia that is determined by drug dose and channel expression. Thus, the response of individuals to these drug types is harder to predict. 🤔 #SVCRS2021 4/5

Moreover, some drugs can block multiple types of channels, meaning there is a complex balance between pro- and anti- #arrhythmia that is determined by drug dose and channel expression. Thus, the response of individuals to these drug types is harder to predict. 🤔

#SVCRS2021
4/5
Michelle Xu (@mich__xu) 's Twitter Profile Photo

#Arrhythmias only occur in a few % of people, so we need to shift the emphasis of screening pills to people. A better insight to the #genetic basis of #proarrhythmia will allow both personalised risk prediction, as well as development of population risk metrics. #SVCRS2021 5/5

#Arrhythmias only occur in a few % of people, so we need to shift the emphasis of screening pills to people. A better insight to the #genetic basis of #proarrhythmia will allow both personalised risk prediction, as well as development of population risk metrics.

#SVCRS2021
5/5
Michelle Xu (@mich__xu) 's Twitter Profile Photo

Thank you Australian Society for Biophysics (ASB) for the fantastic opportunity to present my work! There’s been so many great talks already; can’t wait to see what the next 2 days bring ☺️☺️ #asb2021

Michelle Xu (@mich__xu) 's Twitter Profile Photo

Thank you to everyone who watched my talk last Thursday + gave me kind messages and feedback! It‘s been a long time since I presented in-person (the last one was my Honours in 2018) so it was definitely nerve wracking 😅 St Vincent's Campus Research Symposium Victor Chang Cardiac Research Institute