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If you are measuring total protein content in skeletal muscle and wondering about the origin of the often-cited 'holy number'—that ~20% of muscle is protein—a recent detailed study provides support for it, reporting a value of 17.7%. journals.physiology.org/doi/full/10.11…

A careful and important study for those designing trials on chronic β-alanine supplementation. It will be interesting to see if long-term use (3 months in this study) enhances the body's pH buffering capacity and improves exercise performance in future research.

I believe that, at least for certain fields and subject to each instructor’s discretion, we should transition from traditional “open-book” exams to “open AI” exams.

This isn’t just mental gymnastics—it reframes redox regulation as a systems-level phenomenon rather than an on-off switch. Embracing a proteoform-centric view, it offers insights into how we measure/calculate oxidative stress (multi-site oxidation across proteins). A trailblazer.

Study shows that chronic antioxidant supplementation (VitC+VitE) blunted molecular adaptations to training, yet, no impact on any measure of exercise performance—considering that "antioxidant" is a vague term and that VitC+VitE may not always act as such. biorxiv.org/content/10.110…

I am still unsure if periodization in training truly works—have we even used the best experimental designs to test it? I get the challenges of doing so. But one thing is certain: it definitely works for cooking the perfect eggs! nature.com/articles/s4417…

"Something is Rotten in the State of Redox"—probably the most ingenious title I’ve ever seen in redox biology. The paper on the different meanings of antioxidant is excellent & explains much of "Antioximania", my term for the obsession with antioxidants. mdpi.com/2076-3921/13/1…

In case you need it, the mass of a single muscle cell is ~80 µg. Source: github.com/milo-lab/cellu…

A very interesting webinar today on the Redox Biology of Exercise and Nutrition.

Never hire: A sports scientist who only sees the body as a machine—because you are more than VO₂max & lactate curves. But also not one who only sees the body as a self-organizing mystery—enzymes, lactate etc still matter. You need both models—Context is essential. More here:

If, like me, you thought the first evidence of exercise-induced mitochondrial adaptations came from Holloszy in 1967… think again. Turns out Olga Chepinoga published it in 1939—in Ukrainian. A fascinating historical reappraisal.

Despite the challenges, this well-conducted study found that chronic Theracurmin—a bioavailable curcumin extract—supplementation neither enhanced nor impaired muscle hypertrophy in mice, but simply modulated some inflammatory and oxidative stress markers. journals.humankinetics.com/view/journals/…

An important message from an original thinker in (quantitative) nutrition

James Imlay turns redox chaos into clockwork: his new paper shows how membrane permeability sets the tempo of oxidative stress, with straight-up back-of-the-envelope math in the appendix. Fundamental, elegant, causal. onlinelibrary.wiley.com/doi/10.1111/mm…

Vitamin C+E supplementation blunts molecular adaptations to sprint interval training but not performance gains. Since performance wasn’t impaired, I wonder whether, and to what extent, the blunted molecular responses can truly be considered detrimental. physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

Much of the joy of computational papers lies in how they bring scattered insights together. Even if you don’t model, this one helps experimentalists design better studies by clarifying how training stresses drive specific adaptations across energy systems.arxiv.org/abs/2503.14841

Study challenges taurine as a universal aging biomarker. In humans, monkeys and mice, taurine levels increased or stayed stable with age. Inter-individual variability was high and links to muscle strength were inconsistent. science.org/doi/10.1126/sc…