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Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time

Extremely proud to find this innovative vaccine platform from Michael Fischbach at Stanford. Imagine no more jabs! Low cost and globally deployable. thetimes.com/uk/science/art…

If you read one science thread today, make it this one! Now in nature, the latest work from #CZBiohubSF Investigator Michael Fischbach's team could open the door to receiving vaccines as a skin cream. Also see great coverage by Stanford Medicine's Bruce Goldman: med.stanford.edu/news/all-news/…

Check out our last pub. from Michael Fischbach lab! We discovered that skin commensal microbes induce systemic and local B cell responses upon colonization and took advantage of this knowledge to create topical vaccines using engineered skin microbes. Please read the thread for details.

This is a very important discovery and a brilliant example of engineering a resident skin bacterium to elicit powerful immune responses! This approach has the potential to lead to highly potent vaccines that can be administered as a simple skin cream. Very exciting!

Beautiful work with Djenet Bousbaine Kate Bauman Michael Fischbach Belkaid Lab - skin commensal colonization generates re-directable and potent antibody responses!

Very interesting work Michael Fischbach team, and appreciate the clear educational thread!

Incredible study and great thread!

Biology is wild. Very cool results from a grantee, suggesting prospect for vaccines that could be administered as a topical cream.

Epic thread. Not just a very promising result, but also a good story of how research is done.

👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀 And did I say 👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀

Big leap forward in our understanding of interactions between our immune systems and microbiomes, and a promising path to new and better vaccines

wow 😮 🦠

imo this is one of the most exciting lines of immunology research in recent years

take some time now to read this thread it explains what happens with the immune system when swabbing (no entry!) a bacteria on the head of a mouse it beautifully walks us through the years-long scientific journey and is exemplifies how our competitors are in fact our friends❤️

The skin — once thought to be a mainly passive barrier — can produce its own antibodies that fight off infections nature.com/articles/d4158…

Stand Up To Cancer Scientific Advisory Committee member Michael Fischbach published a paper in nature showing that immunity to a common skin bacteria involves a coordinated T and B cell response, which can be redirected against pathogens as a novel form of topical vaccination nature.com/articles/s4158…

A typical project for an incoming graduate student might involve 1–2 weeks of planning and 2–5 years of execution, [yet] the problem you choose will influence the impact of your work just as much as the quality of your execution. – Michael Fischbach buzzsprout.com/1744020/episod… Michael Fischbach

What an amazing story that was such a blast to collaborate on with Michael Fischbach lab!!! Phenomenal work led by Djenet Bousbaine and all co-authors!! Unroll this thread and be amazed 🤯👇🏾

I’ve been busy this week… 👀 Passed my PhD defense! Insanely grateful for Michael Fischbach. Truly epic scientist and human.