Will this change your practice for severe CAP?! 🫁 New in NEJM: CAPE COD RCT demonstrates hydrocortisone reduces 28d mortality in patients with severe CAP! 🔹 Reduced rate of intubation 🔹 Reduced rate of vasopressor requirement Read more details here: nejm.org/doi/full/10.10…

How Staph aureus manipulates our immune system to cause invasive infections🦠🤒 ⭐Inhibits neutrophil extravasation and chemotaxis ⭐Inhibits complement activation and phagocytosis ⭐Inhibits neutrophil-mediated killing ⭐Kills host immune cells nature.com/articles/nrmic… 1/4

My #pharmageddon 💊🦠 game came in today! Everything looks and feels beautiful, even my super necessary custom abx card 😅, thanks so much Scott! Pharmageddon: Bugs vs Drugs #AntimicrobialResistance #stewardship #IDtwitter #clinmicro

#IDtwitter Mechanisms involved in beta-lactam-induced neurotoxicity CURE ID BCM ID Fellowship ANZPID Ruwandi Kariyawasam, PhD, FCCM, D(ABMM) @andreaprinzi Darcy Wooten she/her 橘子茶 @MeghJoe Irish Society of Clinical Microbiologists Raghav Tirupathi, MD, FACP, FRCP, FIDSA Vindana Chibabhai (she/her) @KyleDHueth DOI: 10.3390/microorganisms9071505

2/ Case continued: Neurosurgical evacuation of the brain abscess was performed. GMS showed hyphae. Culture: Lomentospora prolificans. Which of the following antifungal drugs is most likely an effective treatment?

AmpC β-Lactamases production are regulated by AmpD and AmpR Inducible AmpC = saturation of AmpD due to ⬆️cell wall degradation products after β-Lactam ➡️binding of AmpR which induces AmpC Derepressed AmpC = mutations of AmpD/AmpR ➡️AmpC produced regardless of β-Lactam exposure

Doxy-PEP in a nutshell ➡️Doxycycline for STI prevention: Current research and future directions -Chase CANNON #IAS2023 #IDtwitter #STItwitter (1/3)

Human botulism ➡️Caused by toxin of Clostridium botulinum ➡️5 types (infant, food-borne, wound, iatrogenic, inhalational) ➡️Same clinical syndrome: acute onset of bilateral CN palsy and symmetrical descending paralysis ➡️Typically normal GCS and no fever doi.org/10.1038/nrmicr…