A study from Victora Lab and DM in Science Magazine reveals how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of both food allergies and intestinal diseases. #RockefellerScience bit.ly/4hyS18b

Wondering how enteric neurons and ILC2s chat in the gut? Check out our brand-new Immunity paper! cell.com/immunity/abstr… Huge thanks to our incredible lab, collabs, editors and reviewers!

Precise 3D Imaging of the gut-brain axis in the Alzheimer's disease model science.org/doi/10.1126/sc… Science Advances open-access

Can’t believe it’s the last day of January 2025🤪

extremely disappointed I know nobody cares...

Sad day

Biological systems find ingenuous solutions. Almost anything that can happen, happens. Still, I would not have guessed a role of RNA-binding proteins on the cell surface. The Flynn lab are boldly investigating glycoRNAs and following their leads.

We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their

A precision cellular immunotherapy shows potential to deplete only autoimmune B cells in AChR-seropositive myasthenia gravis Science Advances science.org/doi/10.1126/sc…

CD11c+ CD8 T cells cause IFN-g-dependent autoimmune neuroinflammation that is restrained by PD-1 signaling doi.org/10.1101/2025.0…

Daisong Wang et al report that BEST4/CA7+ gut cells regulate electrolyte and water balance in response to diarrheal bacterial toxins These cells greatly increase in number when exposed to IFNγ cell.com/cell-stem-cell…

Proteins that allow water to move in and out of cells help shape the development of new blood vessels. elifesciences.org/articles/10630…

Wow finally got some hand over bread crumbles! WTF!

Lovely evening at NYC

Good Morning!

I can't believe MHCflurry is still crushing, it also is pretty much the only thing I can use to in any way enrich for hits in targeted MS immunopeptidomics. Tim O'Donnell did a great job dragging a prototype into something that's extremely useful many years later.

Antibodies don't work. NLRP3 is by far the most studied inflammasome — yet <30% of commercial antibodies were specific. Only 4 of 14 tested antibodies detected NLRP3 specifically. Antibodies must be validated before use. Full report by YCharOS zenodo.org/records/116239…

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

New paper alert! We report in Cell Metabolism how serine regulates skin stem cell fate. Congratulations to everyone involved! cell.com/cell-metabolis…

Relaxing Sunday afternoon with @ zori nori coloring book