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Interested in using genetically engineered macrophages for anti-inflammatory applications? Check out my new paper @JTERM demonstrating a novel iPSC-derived engineered macrophage for inflammatory mitigation doi.org/10.1155/2024/6…! Farshid Guilak The Guilak Lab WashU Biomedical Engineering WashU Ortho Research

New content online! Engineering approaches for RNA-based and cell-based osteoarthritis therapies dlvr.it/T1jsYQ

Let’s all be Upstanders! Thank you . Feini (Sylvia) Qu for a great #ORS2024 #DEI session. Orthopaedic Research Society

So amazing to see generations of The Guilak Lab members all together - from Boomer to GenZ! The highlight of this #ORS2024 meeting!

Attending the WashU Center of Reg Med faculty retreat and experiencing the vibrant interdisciplinary regenerative medicine community was truly inspiring! Major kudos for the enlightening session by Farshid Guilak where pearls of wisdom were shared on the art of crafting multi-investigator proposals!

Excited for our team to be part of the new ARPA-H NITRO program to develop new therapies for osteoarthritis! medicine.wustl.edu/news/grant-of-… Setton Group Erik Herzog WashU Biomedical Engineering WashU Center of Reg Med Shriners Children’s St. Louis WashU Ortho Research @WUSTL_Rheum WashU Medicine Genetics The Guilak Lab @WUSTLortho

Analysis of a random selection of papers shared on social media showed no causative link between posting and citations go.nature.com/3TDj4VJ

#AprilIssue | Learn about the application of the emerging field of #immunoengineering to #autoimmune diseases in this #Review from Nisarg Shah Cedars-Sinai and colleagues dlvr.it/T34FXX

And the The Guilak Lab loves you!

📢🌍 International scholars, don’t miss out on the Rita Levi-Montalcini Postdoctoral Fellowship in Regenerative Medicine! 🧬It’s your chance to work with outstanding mentors and access incredible resources at WashU Center of Reg Med. Apply now to kickstart your research career! #postdoc 👇

Chondrocytes have multiple ion channels for sensing mechanical stimuli - in our latest study, Bob Nims MaybeItsBob & Daniel Palmer (w/Bo.博) used RNA-seq to analyze the complete chondrocyte "mechanome" in response to activation of TRPV4 or Piezo faseb.onlinelibrary.wiley.com/doi/10.1096/fj…

🚨After 8y and many dead ends- we are excited to clarify how "stable" adipocyte lipolysis is potently activated independent of catecholaminergic signals while being restrained by glucose and insulin. RT and feedback welcome as we work from preprint to pub! biorxiv.org/content/10.110…

Congrats Ruhang Tang & Natalia Harasymowicz for our new PNASNews paper on gene therapy for fat-1, an enzyme that converts 𝜔-6 fats (frying oil/meat) to 𝜔-3’s (fish/nuts). Increased 𝜔-3:𝜔-6 reduced inflammation, osteoarthritis, and markers of cell aging! pnas.org/doi/10.1073/pn…

Fantastic news that CytexOrtho has received FDA approval for a first-in-human Phase I clinical trial for our 3D woven hip implant! Incredible work by our entire team to reach this milestone. massdevice.com/cytexortho-fda…

Know an undergraduate who wants to pursue a  neuroscience PhD? WUSTL ENDURE empowers participants in their path to graduate school and beyond. Includes $7000 per summer, travel, housing, two scientific meetings/year. Applications due by Feb. 3, 2025. endure.wustl.edu/apply/

Congrats to mollyklimak & team for her latest paper on reprogramming macrophages with smart gene circuits for self-regulating biologic drug delivery - a new way of using cells as an automatic pharmacy! rdcu.be/dZn1a

🎉New publication🎉 Ever wondered how cells transduce mechanical signals to the nucleus? Check out our latest publication from the The Guilak Lab in collaboration with Dr. Marina Danalache lab: doi.org/10.1016/j.bbrc…

Congrats to our education grantees! The grants were awarded to highly motivated and talented young investigators to attend the #ORS Annual Meeting 2025. We look forward to meeting you there! Orthopaedic Research Society @Nefiew328 Jon Blank Thomas Leahy Hope Welhaven, PhD @SungYeon___Kim

We’ve created a new field called “chronogenetics”: controlling gene expression with the cell’s internal clock! Lara Pferdehirt & Anna Damato made living implants that sync to the body and automatically deliver biological drugs on a 24 hr cycle. nature.com/articles/s4146…

Join the ORS Preclinical Models Section for #WebinarWednesday on April 9 at 12 PM CT! Dr. Monica Sentmanat will provide a foundational understanding and practice guidance on the do’s and don’ts, common challenges, and more in transgenic mouse models. Register now: ors.memberclicks.net/pcm040925web