Bob the Grumpy Med Chemist (@med_chemist) 's Twitter Profile
Bob the Grumpy Med Chemist

@med_chemist

Jaded. Let me know when one of you figures out how the human body works.

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calendar_today31-05-2021 19:04:33

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Bob the Grumpy Med Chemist (@med_chemist) 's Twitter Profile Photo

Perhaps a certain journal and its editors could lead the way in changing this culture, to a world where particularly useful negative results are seen as essential to the main body of the paper. Hint. Hint. Wink. Wink.

Bob the Grumpy Med Chemist (@med_chemist) 's Twitter Profile Photo

5 easy steps to become a modern grumpy med chemist: - Have a HTS return no useful hits - Have a virtual screen return no useful hits - Have a fragment screen return no useful hits - Have a DEL screen return no useful hits - Have a literature compound fail to reproduce

Bob the Grumpy Med Chemist (@med_chemist) 's Twitter Profile Photo

Now quite annoyed I didn't get at least 10 J. Med. Chem. papers from the last time I was working on a diastereomeric series: doi.org/10.1021/acs.jm…

Bob the Grumpy Med Chemist (@med_chemist) 's Twitter Profile Photo

I pose the following solution: - Make med chem (somewhat relevant to physicians) a required course for pre-medical students - Make organic a prerequisite for med chem - Organic chem courses are now highly relevant Now all the students get to be even more angry at chemistry!

Bob the Grumpy Med Chemist (@med_chemist) 's Twitter Profile Photo

The Nobel Prize in Chemistry is awarded for the naming of "fancy-name." Though no practical use cases have yet been discovered, the creation of "fancy-name" has led to hundreds of papers and reviews noting the promising potential applications of "fancy-name."

Bob the Grumpy Med Chemist (@med_chemist) 's Twitter Profile Photo

Good thread and responses. And before initiating a study always ask: "how will the med chem/discovery strategy change based on the results of this?" Amazing how often people want to spend time+$$$ on studies that will not change anything besides satisfying intellectual curiosity

Bob the Grumpy Med Chemist (@med_chemist) 's Twitter Profile Photo

Estimated total $$$ spent making compounds based on misanalyzed SAR — chasing noise rather than true signal… A Fermi estimate to absolutely no significant figures: WAY TOO MUCH

Bob the Grumpy Med Chemist (@med_chemist) 's Twitter Profile Photo

Just a reminder to any of you mixing drinks tonight: grapefruit juice is good for masking the taste of alcohol, but beware of juice-drug interactions!

Bob the Grumpy Med Chemist (@med_chemist) 's Twitter Profile Photo

After good data: "May I die if I were to change places with the Persian king!" After bad data: "You know, maybe leaving behind chemistry in exchange for my own kingdom would be a sensible choice if given the option."

After good data: "May I die if I were to change places with the Persian king!"

After bad data: "You know, maybe leaving behind chemistry in exchange for my own kingdom would be a sensible choice if given the option."