Perhaps a certain journal and its editors could lead the way in changing this culture, to a world where particularly useful negative results are seen as essential to the main body of the paper. Hint. Hint. Wink. Wink.

5 easy steps to become a modern grumpy med chemist: - Have a HTS return no useful hits - Have a virtual screen return no useful hits - Have a fragment screen return no useful hits - Have a DEL screen return no useful hits - Have a literature compound fail to reproduce

Now quite annoyed I didn't get at least 10 J. Med. Chem. papers from the last time I was working on a diastereomeric series: doi.org/10.1021/acs.jm…

I pose the following solution: - Make med chem (somewhat relevant to physicians) a required course for pre-medical students - Make organic a prerequisite for med chem - Organic chem courses are now highly relevant Now all the students get to be even more angry at chemistry!

The Nobel Prize in Chemistry is awarded for the naming of "fancy-name." Though no practical use cases have yet been discovered, the creation of "fancy-name" has led to hundreds of papers and reviews noting the promising potential applications of "fancy-name."

Good thread and responses. And before initiating a study always ask: "how will the med chem/discovery strategy change based on the results of this?" Amazing how often people want to spend time+$$$ on studies that will not change anything besides satisfying intellectual curiosity

Estimated total $$$ spent making compounds based on misanalyzed SAR — chasing noise rather than true signal… A Fermi estimate to absolutely no significant figures: WAY TOO MUCH

Just a reminder to any of you mixing drinks tonight: grapefruit juice is good for masking the taste of alcohol, but beware of juice-drug interactions!

Forgot to provide the answer: US20220402883 - COMPOUNDS AND METHODS FOR MODULATING RNA FUNCTION

If I were the patient, I’d be a bit concerned that the “Amount” field of the label is basically unintelligible

Having just read the article, this was quite apparent:

After good data: "May I die if I were to change places with the Persian king!" After bad data: "You know, maybe leaving behind chemistry in exchange for my own kingdom would be a sensible choice if given the option."