Activation of Primary C–H Bonds in Oxidative Cyclizations of Tambjamines Catalyzed by Rieske Oxygenases TamC and PtTamC | Journal of the American Chemical Society Queen's University Queenschem Kingston Ross Group @ Queen’s pubs.acs.org/doi/10.1021/ja…

#ChemBioChem The Biarylitides: Understanding the Structure and Biosynthesis of a Fascinating Class of Cytochrome P450 Modified RiPP Natural Products (Max J. Cryle and co-workers) #openaccess 🔓 onlinelibrary.wiley.com/doi/10.1002/cb…

Ogasawara (A03) and Ushimaru (A01) groups, in collaboration with Prof. Chang in North Carolina State University, revealed the importance of stereoelectronic effect in nonheme Iron enzyme catalyzing cyclopropanation. J. Am. Chem. Soc. doi.org/10.1021/jacs.4…

Single-Enzyme Conversion of Tryptophan to Skatole and Cyanide Expands the Mechanistic Competence of Diiron Oxidases | Journal of the American Chemical Society Brandeis University UC San Diego Scripps Institution of Oceanography UC San Diego Skaggs School of Pharmacy pubs.acs.org/doi/10.1021/ja…

Out today in Angewandte Chemie Evolution-Guided Discovery of Antimycobacterial Triculamin-Like Lasso Peptides doi.org/10.1002/anie.2… Fun collaboration with the Tørring lab Thomas Tørring

Expanding Polycyclic Tetramate Macrolactam (PoTeM) Core Structure Diversity by Chemo-Enzymatic Synthesis and Bioengineering (Tobias A. M. Gulder and co-workers) Manuel Einsiedler Sabine Schneider TAMGulderLab_TechBioDD Antibiotikaforschung (inaktiv) Helmholtz-Zentrum für Infektionsforschung –inaktiv #openaccess 🔓onlinelibrary.wiley.com/doi/10.1002/an…

Thrilled to share our discovery of a novel polyene macrolide antifungal with a unique mechanism of action—targeting fungal membrane phospholipids. Grateful for the collaboration with Prof. Zongqiang Wang’s team at CPU. Check out our paper in nature: nature.com/articles/s4158…

Nature research paper: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome go.nature.com/3FJLuu0

A beauty put together by our Tobias Milzarek Antibiotikaforschung (inaktiv) Helmholtz-Zentrum für Infektionsforschung –inaktiv. It summarizes a huge body of work by many on one of our favorite natural product classes, the sorbicillinoids! Thanks to DFG public | @[email protected] for funding!

The Kuzuyama group (A01), in collaboration with Prof. Jeroen S. Dickschat, has identified a pair of cyanobacterial terpene synthases to produce a rare 6,6,7-tricyclic diterpene alcohol, deepening our mechanistic understanding of terpene cyclases.J. Am. Chem. Soc. pubs.acs.org/doi/full/10.10…

Lab article: We revealed the significance of the cryptic amino group of the quinone intermediate common to the biosynthesis of tetrahydroxynaphthalene-derived meroterpenoids such as furaquinocin/naphterpin. Chemical Science pubs.rsc.org/en/content/art…

excited to see our paper on the total synthesis and biosynthetic logic of Lugdunomycin out in Journal of the American College of Surgeons (JACS). Congrats to Michiel Uiterweerd and Isabel Nuñez. Awesome collaboration with the Minnaard lab. pubs.acs.org/doi/10.1021/ja…

We are hailing a loud "congratulations!" to Postdoc Research Fellow Dr. Lisa Mydy, who accepted an Assistant Professor position with Purdue University's Department of Biochemistry! Dr. Mydy has been a part of the Kersten Lab in the Department of Medicinal Chemistry.

Our work on Taxol biosynthesis is now out at Nature Synthesis. You can read it here: nature.com/articles/s4416… Congratulations to Feiyan Liang and the rest of the Kampranis Lab and thank you Novo Nordisk Foundation DK Frie Forsk.fond and Department of Plant & Environmental Sciences

Interested in natural product producing microorganisms? 🦠 See you in Berlin... 😀

AfD-Bürgermeister Hannes #Loth versprach Entlastung – geliefert hat er Preisexplosion: Eine Familie in Raguhn-Jeßnitz zahlt jetzt über 2.600 € mehr im Jahr. Kita, Steuern, Hund – alles teurer. Willkommen in der #AfD-Realität. #AfDmachtDumm #RaguhnJeßnitz #AfDVerbotjetzt

A new paper reports the genomic discovery and biochemical characterization of a widely distributed gene cluster family for briarane diterpenoid biosynthesis in metazoans nature.com/articles/s4158…

We're happy to announce our paper about the structural elucidation of the antifungal lipopeptide AFC-BC11 from Burkholderia cepacia complex incl. insights into central steps of its biosynthesis published in J. Am. Chem. Soc. ! Congratulations, Lei Zhong 🥳 pubs.acs.org/doi/full/10.10…

Thrilled to share our latest paper just out in J. Am. Chem. Soc.! We uncovered an unprecedented KS domain-catalyzed β-lactonization in the biosynthesis of the HMG-CoA synthase inhibitor hymeglusin. Huge congratulations to Mizuki on his first paper! 🎉 pubs.acs.org/doi/10.1021/ja…

Super happy that EnzyMS, our LC-MS pipeline for detecting promiscuous #enzyme activity, is out in Chem Catalysis ! Testing it on WelO5* + soraphen A uncovered an oxidative demethylation - missed by standard tools. Curious? 👉 cell.com/chem-catalysis…