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Avery Hinks, Ben Dalton, Parastoo Mashouri, Geoff Power (HHNS at UofG), Flewwelling, @lab_cheng (Muscle Health) and Pyle (IMPART) examine the muscle mechanical function change during the perimenopausal transition into early and late menopause! 📜buff.ly/3UHlofS

#newpaper #FoVE group & 1st 1st aurhor by Vonderscher Mylene 👇 Exp. evidence of the fatigue/endurance model proposed by Max Bowen pubmed.ncbi.nlm.nih.gov/38070705/ with Pierre Samozino LIBM UnivSavoieMontBlanc + Method to estimate critical force without exhaustion! 🤯 What we did ? 🧵1/4

The fitted model predicts the exercise fatigability and Time to exhaustion whatever the exercise ! We tested it for various target force fonction (a, x, x^2, sin, cos, exp, square, sigmoïde ...) 👇 🧵4/4

Quantum Physics!

Tuesday is #FoVE meeting day ! For today, Pablo Rozier-Delgado presents the results of a study of his master's thesis : In situ assessment of critical speed in animal locomotion: a proof of concept in gun dogs. a collab with Laboratoire d'Ecologie Alpine 🙏 LIBM UnivSavoieMontBlanc

12 years ago, the revolutionary genetic tool #CRISPR/Cas9 was published in Science, work that Emmanuelle Charpentier and @doudna_lab won a #NobelPrize for in 2020. On #WorldCRISPRDay, read the landmark paper that describes the discovery: bit.ly/3BO74LP

Using #AuroraScientific #1200A and #1400A systems, Tatarenko et al. investigated the hierarchical relationship of #muscle mechanical properties of Klf10 KO mice at macroscopic, microscopic, and submicron levels, to improve whole muscle assessment. pubmed.ncbi.nlm.nih.gov/38096609/

#newpaper Just before HOKA UTMB® Mont-Blanc 2023 I proposed to describe trail runing perf. based on force-velocity concept #casestudy kilian jornet Jim Walmsley 👇 x.com/B_MorelP/statu… We went a step further! I gathered my research group #FoVE @ home to get GPS data of 700 finishers 1/X

#newpaper Force-Velocity-Endurance #FoVE Model: a new method for functional striated skeletal muscle in situ evaluation in murine models 1 year after presentation of the method at the SFMyologie congress it is now published in “Cahiers de myologie” ➡️pubmed.ncbi.nlm.nih.gov/39555883/ 1/5

1) We developped with Max Bowen a mathematical model to describe the #force or #power production capacity depending on contraction velocity and fatigue so to describe the whole muscle function 2/5

2) We setup an experimental procedure so to fit the #FoVE model to data measured directly from the in situ muscle. 3/5

3) We evidenced sexual dismorphism in Wild Type tibialis anterior mice specific of each of the force, power, velocity and endurance aspects of the muscle function. 4/5

It is not possible to fully understand muscle function by assessing isometric strength alone! We proposed a new tool to evaluate the therapeutics in pre-clinical research 🙏Max Bowen Freyssenet Damien Pierre Samozino Anne Cécile DURIEUX C. Hourde Université Jean Monnet Saint-Étienne UnivSavoieMontBlanc LIBM

Presentation of #FoVE #force #velocity #endurance by Max Bowen SFMyologie Congress Math model ➕ exp. procedure Muscle in situ WT mice model👇 ➡️pubmed.ncbi.nlm.nih.gov/39555883/ FSHD mice model👇 ➡️pubmed.ncbi.nlm.nih.gov/39518930/ Transfer to human adductor pollicis in patients ➡️ Soon!

🗣️Post-doc communication🗣️ Had a great time presenting my work about single muscle fiber experiments at the IPE conference at Penn State! 💪 Grateful for the insightful discussions and connections. Thanks to everyone who stopped by! 🙏 #IPExercise2024 American Physiological Society American College of Sports Medicine

Thank you Capucine Trollet and Institut de Myologie for this invitation to present #FoVE (Focre Velocity Endurance) Model apply to isolated muscle mice model and adductor pollicis human model, with Baptiste Morel This model combined with FoVE assessment gives a complete mapping of muscles

Thank you both Max Bowen and Baptiste Morel for this great duo! So happy to have you in Paris at Centre of Research in Myology (UMRS 974) Institut de Myologie to discuss your #FoVE model. Thanks to SFMyologie congress that allowed us to meet last year! Looking forward to future collaborations!

Dear #muscle students, don't miss the MuSkLE Graduate School summer school Infos & registrations: muskle.univ-lyon1.fr Deadline: Jan. 13th 2025 See you in June for the symposium: " Muscle contractions & locomotion in animals and Human" with Leonardo Nogara Università di Padova

Last #FoVE meeting for 2024 with the already-traditional FoVE quiz ! Thank you to the whole team for a fantastic year 🤩 2025 is just around the corner and we're ready! LIBM UnivSavoieMontBlanc

*Mountain running: from trail runners to chamois* youtube link to my talk given this autumn @IFEPSA for those who want to catch up (video in 🇫🇷 but subtitle in 🇬🇧) #force #velocity #endurance in animal locomotion #FoVE UnivSavoieMontBlanc youtube.com/watch?v=QefT0i…