Novel roadmap to target distal cysteines in kinases disclosed: covalent PI3Kalfa inhibitor in Chiara Borsari et al. Matthias P. Wymann @DepBiomedicine@UniBasel_en J. Am. Chem. Soc. #MedChem #CovalentProbes #StochasticApproach #rationaldrugdesign is online at pubs.acs.org/doi/10.1021/ja…

The role of PI3Kγ in the immune system: new insights and translational implications Nature Rev Immunol by Carrie Lucas & Matthias P. Wymann covers #Genetics and #drugdiscovery of #PI3K Now online at doi.org/10.1038/s41577…

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Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα - congrats Chiara Borsari, your paper made > 10000 article views! pubs.acs.org/doi/10.1021/ja…

Need a chemical probe from Department of Biomedicine Universität Basel to explore PI3K signaling? See Chemical Science our newest article on a highly cell permeable covalent PI3Kalfa inhibitor: "Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling".