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Tremendously sad day for Danish science as Novo Nordisk Foundation is closing its flagship protein research institute, arguably the best in the world. CPRatUCPH has been a beacon of science and progress for years. Let's cherish the remaining years & strive to continue the legacy.

Online now! Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction dlvr.it/Sn6VKR

I am happy to propose a model for mammalian #mitochondria UPR signaling, published nature. nature.com/articles/s4158… Mito protein misfolding induces two cytosolic signals –mtROS and mito protein precursor accumulation. These activate the mito UPR via a DNAJA1-HSF1 signaling axis.

Proud and excited about our new paper elucidating how dietary medium-chain fatty acids reduce food intake via GDF15 in mice. See thread below. Department of Biomedical Sciences | UCPH Institut for Idræt og Ernæring Molecular Physiology UCPH Novo Nordisk Foundation Arla Danmark

GDF15 promotes weight loss by enhancing energy expenditure in muscle nature.com/articles/s4158…

Today we report nature a biobank-scale analysis of #mitonuclear interactions, showing how our nuclear genotype impacts mtDNA copy number and even heteroplasmy! Led by Rahul Gupta collab w/ Benjamin Neale Broad Institute MassGeneral News Harvard Medical School HHMI disq.us/t/4ibyjjo

Losing weight vs. sustaining #weightloss Data suggest that weight loss vs. weight loss maintenance are physiologically and psychologically different in many ways Nature Metabolism #obesity nature.com/articles/s4225…

To restore cellular homeostasis, stress responses should be turned off at the right time and place. A paper @nature shows a ubiquitin-dependent mechanism through which unimported mitochondrial proteins silence the integrated stress response. nature.com/articles/s4158…

Happy to share our new study in The Lancet eClinicalMedicine – The Lancet Discovery Science you can preserve weight loss after termination of medical #obesity treatment, but only if you #exercise. Department of Biomedical Sciences | UCPH Clinical Translational Metabolism | UCPH University of Copenhagen Research Simon Jensen Rasmus Michael Sandsdal Bente Merete Stallknecht Jens Meldgaard Bruun sciencedirect.com/science/articl…

Happy to share our recent study (and final paper of my PhD) on the importance of physical activity in the medical treatment of obesity. Published in eClinicalMedicine – The Lancet Discovery Science Department of Biomedical Sciences | UCPH UCPH Healthscience University of Copenhagen Research Clinical Translational Metabolism | UCPH thelancet.com/journals/eclin…

I fully support this 👇

Read our new study: nature.com/articles/s4225… Treatment of obese mice with small molecule inhibitors of mtDNA transcription (IMTs) leads to marked beneficial metabolic effects. The weight is normalized, the fat deposition in liver disappears and glucose homeostasis is normalized.

New! Online now: The mitochondrial multi-omic response to exercise training across rat tissues dlvr.it/T6KTp8

How does space affect #skeletalmuscle in #astronauts aboard the #InternationalSpaceStation? Our #proteomics study shows significant changes in the mitochondria -and more- pre and post mission. Dive deeper into our findings here 👉 rdcu.be/dJZ9G #SpaceBiology #myotwitter

💪 What are the unresolved questions in the regulation of skeletal muscle #insulin action by #reactiveoxygenspecies? 🔥 Carlos Henríquez-Olguín et al. discuss in this latest Review in FEBS Letters: ➡️ doi.org/10.1002/1873-3… Carlos Henríquez-Olguin

Weight-loss maintenance is accompanied by interconnected alterations in circulating FGF21-adiponectin-leptin and bioactive sphingolipids rb.gy/x71tcl Our latest study published Cell Reports Medicine Great collaboration between Clinical Translational Metabolism | UCPH Department of Biomedical Sciences | UCPH Karolinska Institutet

Analysis of PPL with #obesity identifies distinct FGF21, GDF15, and ceramide responses to diverse phases of weight change #weightloss Cell Reports Medicine cell.com/cell-reports-m… #Diet #Exercise

Online now: Weight-loss maintenance is accompanied by interconnected alterations in circulating FGF21-adiponectin-leptin and bioactive sphingolipids dlvr.it/TBGwPd

Muscle matters: the effects of medically induced weight loss on skeletal muscle thelancet.com/journals/landi…