Bio-orthogonal Glycan Imaging of Culture Cells and Whole Animal C. elegans with Expansion Microscopy ift.tt/wyrevGI #biorxiv_bioE

We are happy to finally recognize our 2023 Marvin J. Johnson Award in Microbial and Biochemical Technology winner Matthew DeLisa here in New Orleans! Congratulations Matt!

Matt DeLisa, Christopher Alabi et al Cornell University investigated a reversible bioconjugation method to alter the surface charge of protein cargos in LNPs, employing an anionic "cloak." This approach aimed to enhance electrostatic complexation of LNP formulations pubs.acs.org/doi/10.1021/ac…

A bioconjugation-based approach to remodel protein surface charges using novel anionic tags allows for the functional delivery of proteins using lipid-based nanoparticle carriers NEW #ASAP by Chris Alabi Matthew DeLisa & colleagues CornellChemistry Read it here: go.acs.org/9T2

Many therapeutic proteins require #glycosylation for function. How can we advance #biomanufacturing of human-like glycans on proteins? Maddie DeWinter Derek Wong, Ariel Thames Matthew DeLisa Weston Kightlinger report new strategies in ACS Publications pubs.acs.org/doi/10.1021/ac…

Exciting news from the lab! 👀 We have updated PepMLM on the arXiv.org with new computational and experimental benchmarking results! 🥳 Just as a reminder: we trained PepMLM via a novel span masking strategy that positions peptide binder sequences at the C-terminus of their target

In our latest paper, we've discovered a new PglB enzyme that enables glycosylation of hinge-Fc and full-length IgGs—marking the first instance of full-length IgG glycosylation in bacteria Check out more here: biorxiv.org/content/10.110… #BioTech #glycotime #bacteria

I'm usually not too emotional about paper acceptances, but this one justifies it. 🥹 It doesn't feel real, but PepPrCLIP is now published at Science Advances! Let me tell you its story. 📕 📜: science.org/doi/10.1126/sc… 💻: huggingface.co/ubiquitx/peppr… PepPrCLIP (🌶️📎) began as

Congratulations to Belen Sotomayor on receiving the Dr. Matilde Hidalgo de Prócel Medal, one of Ecuador’s highest honors! This award recognizes her contributions to science and highlights the innovative research happening in our lab #news

Congratulations to Belen Sotomayor for winning Merck’s Best Oral Presentation Award 🥇 and to Deepali for wining Corning’s Best Poster Presentation Award🥇 at the CBE Graduate Symposium! Delisa Lab is on fire, keep shining, team! #science

Congratulations to Belen Sotomayor on her induction into the 𝐁𝐨𝐮𝐜𝐡𝐞𝐭 𝐆𝐫𝐚𝐝𝐮𝐚𝐭𝐞 𝐇𝐨𝐧𝐨𝐫 𝐒𝐨𝐜𝐢𝐞𝐭𝐲 at Yale University as one of the Cornell University representatives! Her leadership, scholarship, character, service, and advocacy embody this prestigious honor #STEM #Leadership

Congratulations to Belen Sotomayor on receiving the Spring 𝟐𝟎𝟐𝟓 𝐀𝐮𝐬𝐭𝐢𝐧 𝐇𝐨𝐨𝐞𝐲 𝐆𝐫𝐚𝐝𝐮𝐚𝐭𝐞 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐄𝐱𝐜𝐞𝐥𝐥𝐞𝐧𝐜𝐞 𝐀𝐰𝐚𝐫𝐝, the highest honor awarded to a graduate student by Cornell University’s CBE Department!

Glycosylation of Structured Protein Domains in Cell-Free Reaction Environments | ACS Synthetic Biology pubs.acs.org/doi/10.1021/ac…

What if bacteria could glycosylate full-length human IgG antibodies at their native site? In our new Nature Communications paper, we discovered an OST enzyme that enables E. coli to do just that for the first time. Belen Sotomayor Matthew DeLisa nature.com/articles/s4146… #glycotime #biotech

Antibodies are important therapeutics, but producing them in bacteria has been difficult due to glycosylation. w/ Matthew DeLisa Belen Sotomayor we discovered an enzyme that can glycosylate the native Fc acceptor sequence. Pretty cool. Nature Communications nature.com/articles/s4146…

PepMLM is out in Nature Biotechnology! 🎭Want a short binder for any target? Just input its sequence + desired binder length → PepMLM unmasks it. Simple? No way? The results speak for themselves. 👇 📜: nature.com/articles/s4158… 💻: github.com/programmablebi… 🤗: huggingface.co/ChatterjeeLab/…

Target sequence-conditioned design of peptide binders using masked language modeling go.nature.com/3UtVc7N

My PhD work is out in Nature Communications !✨For the first time, we show that bacteria can glycosylate full-length monoclonal antibodies. A proof of concept and a key step toward making antibody therapies accessible to all.. nature.com/articles/s4146… #biotech #glycotime #SyntheticBiology

Study led by Cornell University sets the stage for using E. coli to produce fully human antibodies! Read the full paper here 👉 nature.com/articles/s4146… nature.com/articles/s4146…

Intracellular delivery of full-length antibodies via organ targeted lipid nanoparticles biorxiv.org/content/10.110… #biorxiv_bioeng