Designed Endocytosis-Triggering Proteins mediate Targeted Degradation and amplify signaling biorxiv.org/cgi/content/sh… #bioRxiv

“Fortune favors the prepared mind.” We @abu_remaileh and team serendipitously discover that CLN5, a genetic risk factor for Alzheimer’s disease, encodes the long-sought bis(monoacylglycero)phosphate synthase (BMPS) published in Science Magazine. (1/11) science.org/doi/10.1126/sc…

Update on histone H3 copper reductase activity: Purified native yeast nucleosomes also act as enzymes & optimal activity depends on Zn. This could explain known Zn, Cu interplay & raises the possibility that DNA may be involved in electron conductance. 1/3 biorxiv.org/content/10.110…

Yesterday I defended my thesis in front of many dear friends and family. After so many years of hard work, it felt amazing to share this moment with them. Proud to finally say that I’m #PhDone!

We’ve always wondered if there was something beyond CRISPR for genome editing. We now report that animals, plants, fungi and viruses have troves of programmable nucleases capable of efficient gene editing in human cells An update on our Fanzor work! science.org/doi/10.1126/sc… 1/7

FTC vs Sanofi/Maze: very bad precedent for gov't overreach. And bad in general for patients in all disease areas FTC continues to create friction in the deal mkt that is so vital to our collaborative biotech ecosystem reliant on external innovation globenewswire.com/news-release/2…

As it turns out, the secretion channel Sec61αβγ has a fourth subunit, RAMP4—long overlooked because it falls off in detergent. It holds the pore open and completes the lumenal funnel. This plus exciting structures of TRAP, uL22, & more are now online: biorxiv.org/content/10.110…

The Kampmann Lab at UC San Francisco is looking for staff research associates (technicians). Great opportunity to gain research experience for 2 years before applying to grad school! Supportive and diverse training environment. Please RT - thanks! Apply here: sjobs.brassring.com/TGnewUI/Search…

How to pick a problem. Today in Cell. 1/53 cell.com/cell/fulltext/…

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. Djenet Bousbaine led the charge... nature 1/55