Heading to #ICEM2022 but first a (6-hour) hydration stop in Toronto Matt Schaich

Great DNA repair platform session Environmental Mutagenesis and Genomics Society #ICEM2022 lead by Tyler Weaver with fantastic trainee talks! Griffin Welfer Priya Raja @structureSara

It took a few years, with a global pandemic and transatlantic relocation in the middle of it. But finally, our manuscript on how UV irradiation remodels the specificity landscape of transcription factors is on BioRxiv biorxiv.org/content/10.110…. Huge thanks to...

Excited to announce our SMADNE paper is now out at @NAR_Open, academic.oup.com/nar/advance-ar…, Incredibly proud of the hard work by Matt Schaich, @BrittSchnable , and Namrata Kumar , LUMICKS too!. We hope all of you will use it to study your favorite fluorescent DNA binding protein!

Researchers in the Van Houten Lab used the cutting-edge C-trap to investigate how DNA repair proteins identify and bind to forms of damage, providing an unparalleled level of detail that could someday be used to halt cancer in its tracks. Ben Van Houten inside.upmc.com/fishing-for-pr…

How does DNA get repaired? 🔍We’ve now got the tools to find out >>> bit.ly/3JfEXFd Ben Van Houten Matt Schaich @BrittSchnable Namrata Kumar @NAR_Open

The culmination of Max Fairlamb🔬🔛🧬 thesis work is out Journal of Biological Chemistry! 🥳 Max built a #smTIRF system to investigate how DNA repair intermediates are passed between APE1 and Pol Beta. It's all about Pol Beta probing for damage. 🙏 Maria Spies, PhD (she/her) Washington Lab. tinyurl.com/BER-choreograp…

Thrilled to have Ben VanHouten from University of Pittsburgh at our Amsterdam HQ. Fascinating insights on his groundbreaking nuclear extract technique, #SMADNE. This innovation accelerates sample prep and offers unique glimpses into molecular mechanisms. Read our blog bit.ly/45TRZmo

Excited to share my fourth and final review IJMS MDPI wrote during my PhD where we described the great work from the Ben Van Houten lab showing the direct role UV-DDB has in Base Excision Repair! Check it out here: mdpi.com/2343482 ⚒️🧬

Delighted to be a part of this exciting paper by the Chang/Moore lab driven by James Wan, which studied Merkle Cell Large T in real-time on the LUMICKS C-trap using SMADNE. A surprising result! pnas.org/doi/epdf/10.10… Nice story by Asher Jones: inside.upmc.com/how-skin-cance…

CONGRATULATIONS DR. Sanjana Thosar 🥳🎊🍾 on an amazing defense! My ALT-ime fave DNA repair enthusiast 🧬🛠️ Patricia Opresko, PhD

Find out how your laboratory can utilize the same groundbreaking single molecule analysis techniques to gain direct evidence of DNA-protein binding by attending this Nature webcast. Click here to reserve your place! bit.ly/47X2xSH youtu.be/h9HhwIQu4go

Ready to show off my smug enthusiasm for DNA repair 🧬🛠️

Proud to announce that Brittani's and Matt's beautiful work-up of TDG has appeared in BioRxiv, check it out and let us know what you think - stay tunes as the story will get more interesting soon. biorxiv.org/content/10.110…

This October I’m drawing one molecule a day inspired by proteins in pdb Protein Data Bank rcsb pdb 💉🧬💻🔬💊🌱🧠🦠 Day 27/31 Prompt BEAST Telomerase TERT in action. Telomerase extends telomere sequences at chromosomal ends to protect genomic DNA pdb 6USP Next SPARKLE #sciart #telomere #inktober

So cool for our structure, Matt Schaich, to be featured by such a talented artist!

Important study on comparing purified OGG1 to OGG1 produced in mammalian cell extracts using SMADNE. Thanks to Matt Schaich, Tyler Weaver, and @freudlab for this exciting collaboration. Single-molecule analysis of 8-oxoguanine glycosylase 1 - ScienceDirect

Matt Schaich Tyler Weaver Bret Freudenthal authors.elsevier.com/a/1iRbU5aisDX%… Single-molecule analysis of purified proteins and nuclear extracts: Insights from 8-oxoguanine glycosylase 1DNA Repair, Volume 134, February 2024, 103625

🧬The latest lab preprint is a collab with Marc Greenberg and has some great structures from Ben Ryan (Ben Ryan) and Peyton Oden! 👏 We investigated how Pol Beta bypasses templating Fapy•dG, inserts Fapy•dGTP, and extends from Fapy•dG at the primer. biorxiv.org/content/10.110…