🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

UK-REBOA results: REBOA increased mortality at 90 days and at all interim time points. REBOA increased deaths due to bleeding at 3 hours and 90 days. REBOA substantially delayed time to definitive haemorrhage control. 💢🎈💢 #ccr23

Late breaking at #CCR23: In the PATCH-Trauma trial involving adults with major trauma, treatment with tranexamic acid did not result in a greater number of patients surviving with a favorable functional outcome at 6 months than placebo. nej.md/43zNuMj

From 13:30 tomorrow (GMT), Prof. Giacomo Monti & Prof. Giovanni Landoni, MD from San Raffaele Anesthesia and Intensive Care will present #MERCYtrial results. Looking forward to their presentation, the editorial from Flavia Machado, and the comments from great panelists. PLEASE DON'T MISS IT😉 #CCR23

THE SESSION of #MERCYtrial HAS STARTED! Giovanni Landoni, MD Giacomo Monti San Raffaele Anesthesia and Intensive Care #CCR23

Time above MIC is an important determinant for beta-lactams, including meropenem. So, continuous infusion of meropenem is likely to exert efficacy compared with intermittent administration. #CCR23 Critical Care Reviews

A previous meta-analysis of RCTs showed a decreased mortality when beta-lactams are administered continuously, but there are several risks of bias. So, we designed and performed #MERCYtrial, a multicenter randomized clinical trial. #CCR23

Infographic of the trial design Both groups received an initial loading dose (1g of meropenem). Double-dummy administration Primary outcome: a composite of death or PDR/XDR bacteria emergence at day 28 Culture collection schedule #CCR23

Primary outcome: a composite of mortality or new emergence of PDR/XDR bacteria at day 28 No significant difference in the primary outcome, each component of the primary outcome #CCR23 #MERCYtrial

We've just presented and published a multicenter RCT at #CCR23 and in JAMA! Continuous vs Intermittent Meropenem Administration in Critically Ill Patients with Sepsis: The #MERCYtrial! 🔗 jamanetwork.com/journals/jama/… This 🧵 will explain the study in detail /11 #FOAMcc

10/ It's our honor to publish the results of #MERCYtrial in JAMA JAMA: Continuous vs Intermittent Meropenem Administration in Critically Ill Patients with Sepsis 🔗 jamanetwork.com/journals/jama/… #FOAMcc

Continuous administration of meropenem, compared with intermittent administration, does not improve clinically relevant outcomes in critically ill patients with #sepsis. ja.ma/440XrSP #CCR23

Editorial: "Monti and colleagues are to be commended for their well-designed and well-executed contribution to the controversial literature assessing dosing of β-lactam antibiotics in critically ill patients." ja.ma/3qEaniY #CCR23

It is my honor to work with the excellent team of this fantastic randomized clinical trial. Every piece I learned during the manuscript writing process is invaluable. I appreciate all the people involved in this study. #MERCYtrial #CCR23

🔥🆕️MERCY RCT🆕️🔥 Continuous administration of meropenem, compared with intermittent administration, does NOT improve clinically relevant outcomes in critically ill patients with sepsis. #IDTwitter jamanetwork.com/journals/jama/…

Meropenem en infusión 🆚 intermitente en pacientes con Sepsis 💊 🦠 No hay diferencias en mortalidad 🟰 jamanetwork.com/journals/jama/…

7 new anesthesiologists graduated today in Milan Università Vita-Salute San Raffaele Ospedale San Raffaele 101 are queuing up Matteo Marzaroli Barbara Ferrara isabella.chiodega

San Raffaele Anesthesia and Intensive Care Università Vita-Salute San Raffaele Ospedale San Raffaele Matteo Marzaroli Barbara Ferrara isabella.chiodega Giacomo Monti Marina Pieri Elena Moizo Martina Baiardo Redaelli Stefano Turi Maria Grazia Calabrò, MD Fabrizio Monaco, MD Alessandro Belletti Tommaso Scquizzato, MD Rosario Losiggio, MD #mercytrial presented by Matteo Marzaroli

Could pirfenidone prevent pulmonary fibrosis in #ARDS patients? Our multicenter #PIONEER RCT will answer this question! Full methodological manuscript now available at doi.org/10.1016/j.cct.… San Raffaele Anesthesia and Intensive Care Giacomo Monti Giovanni Landoni, MD Matteo Marzaroli Marco Manazza