Have you ever wondered why some cell lines are easy to edit with CRISPR-mediated gene editing, while others are more difficult? Our paper is now online and offers an interesting answer: nature.com/articles/s4158…

This is a great preprint, and this phrase in particularly is absolutely fantastic, 10/10

Less than 5 days to go for our protein design competition at Adaptyv Bio! We just updated the competition page with a virtual leaderboard for the top 10 designs ranked according to iPAE. Will be updated daily till the submission deadline on Sunday Aug 18! Can you beat the

Blender soft body simulations are great for animating squishy things like cells, but they break if you make cells divide. So I'm building my own cell growth soft body simulator from the ground up in blender geometry nodes. Hope to release this tool soon. #b3d

More than 700 designs by 90 amazing protein designers were submitted to our protein design competition! Given this awesome turnout we've decided to increase the number of proteins to be tested in the lab to 200 in order to validate more designs Check out foundry.adaptyvbio.com/egfr_design_co…

Very happy collaboration with Prof. Yan Yu group Yan Yu Group! We visualized rotation of V-ATPase using Janus nanoparticle and measured torque using the fluctuation theorem! Visualizing Single V-ATPase Rotation Using Janus Nanoparticles biorxiv.org/content/10.110…

Code available upon reasonable request

Lots of great suggestions! SmithLabUMBC mentioned sulfate. But then this was definitely not present in the buffer. But there was a sulfur containing chemical.. the DMSO solvent in which the ligand was dissolved in. Probably exchanged with the Chlorines..

Did AlphaFold solve the protein folding problem? ...Not yet! AF2 predicts static structures, usually the native state by default. However, we found AF2 can generate structures aligning well with known folding intermediates. biorxiv.org/content/10.110… Alberto Perez UF Chemistry 1/n

6 main figs and 5 supplementary figs .

Jiankui He Absolutely criminal, your lack of ethics and scientific rigour should preclude you from ever doing science again

We need a Gordon Ramsay's Kitchen Nightmares for science. Gordon going into struggling labs, revealing the horrors lurking in fridges and file drawers, calling a postdoc a donkey.

this desk setup hurts me to watch ref: openai o1 promo vid on genetics

Years ago, we discovered that missense mutations in homomeric proteins can induce their supramolecular assembly, as in the 📽️👇 - Question: how are such aberrant assemblies of *folded* proteins handled in a eukaryotic cell? The answer here: biorxiv.org/content/10.110… + 🧵 below

Soluble #GPCR homologues? Wow! We’re pretty impressed by this effort from @befcorrei and EPFL & SIB researchers. nature.com/articles/s4158…

Wow, this is really unexpected! Designs were done together with Lennart Nickel in Bruno Correia lab. Our pipeline will be fully open source and preprint online hopefully next week 🙂

Kelvin Lau always @klausenhauser on ☁️ 🪡 🐘 5/153 (3%) is pretty good!! And the winning protocol from Martin Pacesa had success rate of 1/5 (20%) Prior work on EGFR had success rates far below 0.1% see: youtu.be/JpLFhnVARVw

The Protein Design Competition results are in! 🧬 200 designs tested in our lab 🌍 90 protein designers from around the world 💎 5 novel binders found 🎯 2.5% hit rate (vs 0.01% on previous EGFR work) 1st place: Martin Pacesa & Lennart Nickel 2nd place: @khRRustamov

The top binder from the competition was EGFR_l138_s90285_mpnn2, designed by Martin Pacesa and Lennart Nickel. Martin and Lennart used a structural hallucination approach where an initial random sequence is continually optimized by backpropagation through the AlphaFold2 network