Finally out! Genetic engineering of mammalian RNAi in vivo: 1) change Dicer gene to express a truncated variant. 2) add a transgene expressing long dsRNA. 3) add a targeted reporter. We see RNAi but with siRNA levels at par with highly abundant miRNAs. doi.org/10.1038/s44319…

A huge thank you to everyone who contributed towards this week's #AncientBio24 conference! We've heard some excellent talks throughout the meeting, and made some new friends working across many aspects of #AncientDNA A special thanks to Zandra Fagernäs, PhD for the X updates!

Thanks to #AncientBio24 and Wellcome Connecting Science Learning and Training for allowing me to share my research on mammoths and aRNA 🦣🦣

"Analysis of coding gene expression from small RNA sequencing" Our latest work, now in bioRxiv: biorxiv.org/content/10.110…

Woolly mammoths survived on Wrangel Island until 2000 BC! But why did they go extinct? Were they doomed once stuck on the island? We went to Siberia, collected bones & teeth, and sequenced 21 complete genomes. Here is what we found (🧵) Paper in Cell: cell.com/cell/fulltext/…

Today’s issue of Cell has 2 mammoth papers (w. CPG staff)! Marcela Sandoval-Velasco et al. presents a discovery of 3D structure in the Chris Waddle mammoth genome: cell.com/cell/fulltext/… Marianne Dehasque et al. disentangles the mammoth’s extinction using 21 genomes: cell.com/cell/fulltext/…

A raiz del nuevo estudio publicado ayer en #Cell sobre estructuras 3D de ADN halladas en mamuts, expongo algunas modestaa opiniones al respecto. Link al paper (merece la pena leerlo con detenimiento!!): cell.com/cell/fulltext/… abc.es/ciencia/emilio…

It was great to see such a large Copenhagen group at #SMBE2024 organizing several symposia and presenting many talks and posters. We look forward to hosting you in Copenhagen for #SMBE2026! (tag people I missed from the photo 😬)

Next week will have July's #AaRCTikTalks🐻‍❄️ with 2 amazing speakers: Emilio Mármol Sánchez will talk about his groundbreaking work on ancient RNA of woolly mammoths, while Katia Bougiouri will show her results on dog evolution using imputed genomes. Save the date!

📺Sortim al TeleNotícies Vespre de TV3 (3Cat)! 🧬Descobreix el nostre estudi dels fòssils de cromosomes antics a la pell d'un mamut de 52.000 anys Un gran reportatge de Lorena Garcia Leyva, marta catafal i Elena Serra ℹ️cnag.eu/news/fossils-a… 📽️youtu.be/cZkKHVHzG5c

In an hour or so we'll have our #AaRCTikTalks for July, featuring Emilio Mármol Sánchez and Katia Bougiouri displaying two topics on the very edge of aDNA research: aRNA and imputation for ancient genomes. Do not miss them!

The Epigenetic Time Machine has officially launched! Out today in Nature Communications - our chromatin profiles from century-old FIXED specimens! nature.com/articles/s4146… A game-changer for museums! Dr Erin Hahn (she/her) Dr Marina Alexander Celine Frere Nicola Jackson

And when Olivia got mad because they took her son away from her, real 😭

Welcome to being a PI

We are excited to announce a postdoc scholarship to study stop-codon read-through using Omics and molecular biology! The position is shared between the Ylva Engström lab and the Friedländer lab. Feel free to share! 🔬🧬 SciLifeLab Stockholm University scilifelab.se/career/postdoc…

Scientific #Breakthrough- #RNA from a century-old #Tasmanian tiger has been sequenced! This milestone offers fresh insights into its biology. Lead author Emilio Mármol Sánchez of SciLifeLab calls it a game-changer for paleogenomics. #Ecology #Conservation shorturl.at/E4twQ

These paleogeneticists are winners of the 2024 Gizmodo Science Fair for recovering RNA from a museum specimen of a thylacine gizmodo.com/science-fair-t… Centre for Palaeogenetics Emilio Mármol Sánchez Friedlander lab Love Dalén The Fromm Lab Nikolay Oskolkov Zoé Pochon Panos Kalogeropoulos Vaishnovi Sekar

biorxiv.org/content/10.110…

With the Nobel prize to microRNAs in 2024 and the Nobel prize to aDNA in 2022 it looks like what I did during my PhD and what I am working on right now is kind of the medley field to be at. But maybe I am just arriving 30 years later to the party 😅

Arctic animals are uniquely adapted to tolerate the cold. Which are the genes behind these adaptations? And, crucially, when did selectively important mutations in these genes occur? Come join my group for an ancient DNA journey through evolutionary time!