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"Get ready to focus on your brain, because according to the AAN, the era of preventive neurology has arrived." 🧠 👍 Thank you, CNN and @nsanar for sharing our #BrainHealth vision. cnn.it/3SW0o4d #Neurology

Many years ago I claimed covid was damaging the immune system I did have confidence it would be consensus soon Now it's in Science, published unequivocally Where are the people that promised it didn't? 10.1126/science.adn1077

rituximab vs. mavenclad for multiple sclerosis. This retrospective observational study found MRI activity was much lower in those receiving rituximab (17% vs 57% over a median follow up of 4.5 years), but side effects more common with rituximab pubmed.ncbi.nlm.nih.gov/40415655/

BioVie: Long COVID Treatment Landscape and BioVie’s ADDRESS-LC Trial (Hosted on April 10, 2025) A virtual investor event featuring key opinion leader (KOL) Lindsay McAlpine MD, Yale, to discuss the unmet need & current treatment landscape for long COVID youtube.com/watch?v=vx1p19…

Bloomberg: 'The Silent Virus Behind Mono Is Now a Prime Suspect in Major Diseases' 'Epstein-Barr virus, which causes glandular fever, was once dismissed as a rite of passage. Scientists now link it to cancer and multiple sclerosis' bloomberg.com/news/articles/…

Very pleased to co-write this review with Bruce Cree and Steve Hauser on the future of #multiplesclerosis treatment onlinelibrary.wiley.com/doi/10.1002/an…

Potential new therapies for MS (CAR-T cells, BTKIs, HSCT, remyelination, high dose b-cell depleters) and the newly understood pathophysiology of MS. From UCSF. pubmed.ncbi.nlm.nih.gov/40474602/

The path to prevention of #MultipleSclerosis: Considerations for Epstein-Barr virus vaccine-based prevention studies. Future perspective from University of Washington bruce bebo National MS Society ▶️ journals.sagepub.com/doi/abs/10.117…

Chicago researchers found that gut inflammation lets CD4 T cells trained on gut bacteria invade the brain and trigger neuroinflammation, suggesting that microbiota-specific immune responses can contribute to neurological disease. nature.com/articles/s4158…

Is it time to tame the brain’s fire? Neuroinflammation is emerging across Parkinson's, Alzheimer's, neurodegeneration and beyond. An important new Science article from Shi and colleagues pulls back the curtain on neuroinflammation. Could this be a silent driver of destruction in

A recent review highlights neuroimmune drivers of Long COVID: glial activation, BBB dysfunction, endothelial injury, neurotransmitter imbalance, and neuro-degeneration. Beyond antivirals and MABs, here are a few pharmacologic tools I utilize to manage neurologic phenotypes. 🧵

Effect of Cumulative Exposure to Ocrelizumab on Memory B-Cell Repopulation Dynamics in Multiple Sclerosis onlinelibrary.wiley.com/doi/10.1002/an…

Rituximab showed superior effectiveness on MRI and clinical activity, compared to cladribine, over 4.5 years. Observational data from the Norwegian #MultipleSclerosis Registry and Biobank Universitetet i Bergen Universitetet i Oslo ▶️ journals.sagepub.com/doi/full/10.11…

Tissue-resident memory CD4+ T cells infiltrate the CNS in progressive multiple sclerosis and contribute to chronic autoimmunity in mice science.org/doi/10.1126/sc…

UCSF scientists and collaborators suggest SARS-CoV-2 may mimic cancer by persisting in the body, evading immune detection, and disabling tumor suppressor genes like p53 and RB.

In long COVID patients, researchers observed chronic immune dysregulation, exhausted T cells, and reduced cytotoxic NK cells hallmarks also seen in viral-related cancers.

Study finds brainstem reduction & deformation in #LongCovid patients aged 20-50. They found cerebrospinal fluid (CSF) flow velocity is significantly reduced, & deformities in the 4th ventricle & cerebellar peduncles, suggesting impaired CSF dynamics. medrxiv.org/content/10.110… 1/

📢 More evidence that #LongCovid and #Dysautonomia are associated with #neuroinflammation of the brainstem comes from this new study from Germany and UK. 👇 medrxiv.org/content/10.110… ‼️ The new study reaffirms my prior assertion that #POTS and #Dysautonomia in general localize to

Funding into women’s health massively neglects funding immune diseases that disproportionately affect women. Arguably the diseases causing some of the most extreme suffering to women, yet neglected from the scope of traditional women’s health funding. This needs to change.

Zürich researchers found that in humanized mice, EBV triggers B cells to enter the brain, where they attract inflammatory T cells. This lymphocyte infiltration may kickstart multiple sclerosis, revealing a possible mechanistic link between EBV and MS. nature.com/articles/s4158…