New publication out!

GCA affects patients above 50 years old. Could senescence play a role in the immunopathology? Our data indicates yes. More research is needed to dive deeper into this topic. Yannick van Sleen Elisabeth Brouwer Vasculitis Groningen onlinelibrary.wiley.com/doi/abs/10.100…

Happy to anounce that we can continue inclusion of patients in our Leflunomide trial in PMR funded by ReumaNederland thanks to a generous gift from the department of Rheumatology and Clinical Immunology ZGT Almelo @LennyGeurts Marieke van Nieuwland

van Nieuwland et al. Comparison US/PET/MRI in GCA. Good specificity but relatively low sensitivity for all. PET best for extra-cranial. MRI/US best for isolated cranial. Dr. John Cush #ACR22 Abstr#1617 acrabstracts.org/abstract/direc…

#ACR22
Oral Abstr 1617:🌟MRI vs US vs FDG-PET/CT for diagnosis of GCA

A worthwhile question!

👉Overall high specificity and PPV across all modalities, but lower sensitivity:
👉MRI misses extra-cranial GCA
👉FDG-PET/CT misses cranial GCA

Perhaps a multimodality approach?

What imaging modality is best in GCA?

Dutch study: n=42
?GCA got all three of USS, PET/CT, MRI

Overall performance basically the same between all three.

Important details in 🧵
but reasonable to say you can be happy with whatever you’ve got!

ABST1617 #ACR22 #ACRBest Dr. John Cush

Enjoyed talking about imaging modalities in patients with suspected #GCA this afternoon at #ACR22 Vasculitis Groningen

'Discussing' the posters and talks of the amazing vasculitis 2022 congress #Vasculitis22

What is the role of CD8 T cells in GCA? Excellent presentation by dr. Rosanne Reitsema from our group! #vasculitis22

Love this cartoon from Elisabeth Brouwer and colleagues. The actual message of their study is that US, PET, and MRI are all good early diagnostic methodologies in the appropriate clinical scenario #Vasculitis22