So stoked to be sharing this! New proteomics map of human subcellular architecture. CRISPR + organelle IP mass spec at scale. Check out pre-print biorxiv.org/content/10.110… and organelles.czbiohub.org. 🙌 to fantastic team Chan Zuckerberg Biohub Network SF & collabs! 1/2

I am super excited that our team has received the WWTF grant 🥳 to identify determinants of breast cancer #metastasis by building multimodal tissue maps using AI/ML. Psyched 🤩 to get started with André Rendeiro CeMM & Zsuzsanna Bagó-Horváth Center for Cancer Research MedUniWien Center for Cancer Research MedUniWien

Check out our new preprint, describing the transcriptional and proteomic events during Vaccinia virus infection in human cells. Spearheaded by the incomparable Alex Matía @alexmatia.bsky.social, who spent a few super productive months with Carolina Arias Lab and me at the Chan Zuckerberg Biohub Network. #LoveVirology #PoxRocks

"I can’t wait to see what we will discover next . . . 'Looking' at cells is a central pillar of cell biology. I will bet that cells are not done surprising us." 🔬 #CZBiohubSF's Manuel Leonetti in Cell's 50th anniversary issue. cell.com/cell/fulltext/…

In order to ensure Europe’s competitive edge in global science and technology, the ERC Scientific Council calls for a doubling of the budget of the next EU research framework programme (FP10) and maintaining the ERC’s independence. Read the statement: erc.europa.eu/news-events/ne…

Greenhouse Effect xkcd.com/2889

Thrilled to share that Dynamo v1.4 (github.com/aristoteleo/dy…) for single cell and metabolic labeling enabled RNA velocity vector field learning and prediction is now on PyPi! This is one of our biggest upgrades of Dynamo since early 2023. In this new release, we made the following

We report a new CRISPR resource, Fragmid, in Cell Genomics today, let by the incomparable Abby McGee. Let's walk through it… cell.com/cell-genomics/…

Why do patients die from cancer while others survive? Join us Center for Cancer Research MedUniWien in Vienna to find out! I am recruiting a #PhD candidate to work on solving the puzzle 🧩 of #metastasis using #singlecell & #spatial omics 👩🏽‍💻🧑‍🔬Apply by April 15 ⏰ Find out more 👉tinyurl.com/bdz9yv5v

Excited to share with you our manuscript describing the endogenous protein La as a mediator of prime editing and the development of our PE7 editor, which can improve prime editing. For more, please check out nature.com/articles/s4158…

Super excited to share my ✨first senior paper ✨ describing a myeloid TLR-NFκB inflammation signature in the premetastatic niche. Thanks to Ansu Satpathy for the great collaboration and kudos to the one and only cmcginnis check it out👉doi.org/mzpm

How much do you think?

📢🧬 #CRISPR paper + software published in Nucleic Acids Res. protospacejam.czbiohub.org an all-around platform for knock-in design. Fully opensource code could be re-used for other applications. 👏 to Duo Peng the wizard behind all this + Chan Zuckerberg Biohub Network team 🙌 doi.org/10.1093/nar/gk…

Research from #MedUniVienna in collaboration with Stanford University and UC San Francisco provides unprecedented insights into the dynamic remodelling of #immunecells in the metastatic niche from early #tumour development to late #metastasis. ➡ bit.ly/3WfkM1X Cancer Cell Juliane Winkler

I am very grateful to work with so many talented and motivated trainees and colleagues. Shared Hein Lab, Barozzi lab and Winkler lab outing at a traditional Heuriger vineyard in Vienna. ☀️🍇

We are looking for a highly motivated PhD student for a joint project with the Köhler Lab Max Perutz Labs Vienna. We will explore the molecular mechanisms behind tardigrade cryptobiosis using advanced LC-MS and metabolomics techniques. Apply at training.vbc.ac.at/phd-programme/…

Paper alert 🤩 stoked about publishing our story on transcriptional heterogeneity of breast cancer, profiling primary tumors and their matched metastases at single-cell resolution. out today in Journal of Clinical Investigation jci.org/articles/view/…. check out the 🧵of the pre-print 👇 1/n

#AITHYRA is born! 🎉 OeAW is founding a new institute at the intersection of #AI & #biomedicine – the AITHYRA Institute. Meet the new founding director and DeepMind Professor of Artificial Intelligence Michael Bronstein. Watch now ➡️youtu.be/pTA6DPQpxfo #boehringeringelheimstiftung

🚀 Let’s dive into the topic #protein in time and space at #MetabolismInAction2024 with Manuel Leonetti from Chan Zuckerberg Biohub Network 🗣️ Global organelle profiling reveals subcellular localization and remodeling at proteome scale #science #Innovation #metabolism Novo Nordisk Foundation

In collaboration with Reuben Saunders, Jonathan Weissman's Lab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! biorxiv.org/content/10.110…