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Anti-Slit antibodies: what’s the target? They can be present even without typical immune deposits, suggesting a pathogenic mechanism different from other autoimmune glomerulopathies. Valentina Raglianti #ERA25

▶️ APRIL is a key factor in pathogenesis of IgAN ▶️ Sibeprenlimab inhibits APRIL ▶️ Phase 2 trial of Sibeprenlimab reduced proteinuria ▶️ Visionary trial is a large, international, RCT ▶️Primary endpoint: proteinuria ▶️ First 320 patients will be reported today ( proteinuria

In this paper we describe group of patients with MN who had negative IF for PLA2R but had PLA2R detected by LM/MS! Kidney International ⁦Sanjeev Sethi⁩ ⁦Ilario Russo, MD⁩ ⁦fernando fervenza⁩ kidney-international.org/article/S0085-…

🧪 Anti-CD38 targets plasma cells, aiming to reduce DSA production 📉 Early studies suggest daratumumab/felzartamab may lower DSA & can stabilize graft function. 🚧More RCTs needed to define long-term benefit & safety. #ERA25 #AMR #Desensitisation #NephTwitter

#Complement Activation in Secondary Thrombotic Microangiopathies (#TMA) ✅ Final version available in #OpenAccess in NDT ➡️ academic.oup.com/ndt/advance-ar… 🙏 experts, colleagues and friends; the ERA - European Renal Association Immunonephrology Working Group; and Andreas Kronbichler for your leadership!

LMD/MS was done on PLA2R negative MN cases to find the underlying antigen for discovery of NELL1, EXT, FAT1, NDNF, etc. by our group. As a side story we found that ~3% of cases that we thought were PLA2R neg turned out to be PLA2R ➕ by LMD/MS. That is the message of our paper.

Antiphospholipid Nephropathy #APS Classification, histologic definition and management #EULAR2025

🧐NEW Review: Decongestion in patients with advanced chronic kidney disease coexisting with heart failure ❤️ 🆓doi.org/10.1093/ckj/sf…

Role of APRIL in IgA Nephropathy #IgAN #Nephpearls 👉🏼 nephu.org/iga-nephropath…

Characterization of #Monogenic Kidney Disease in #Older Patients With #CKD #VisualAbstract by Krithika Mohan kireports.org/article/S2468-… Elhussein Elhassan Peter Conlon RCSI_StAR MD RCSI Beaumont Hospital Irish Nephrology Society Matthew Griffin Anthony Bleyer Wake Forest University School of Medicine 1. lékařská fakulta Univerzity Karlovy

Alport spectrum

Kidney Dysfunction in Heart Failure: Core Curriculum 2025 - American Journal of Kidney Diseases ajkd.org/article/S0272-…

Patients with CKD G3b-G5 have a higher risk of kidney disease progression due to higher blood pressure, emphasizing the importance of maintaining optimal blood pressure over time. kidney.pub/CJASN0760 #ASNCJASN

Renal prognosis in AL amyloidosis has been traditionally determined by categorizing patients into 3 renal stages at diagnosis (Palladini model). Our revised Renal Staging System (4-stage model) more accurately predicts progression to renal failure Haematologica The International Society Of Amyloidosis

Our revised definition of Renal progression in AL amyloidosis more accurately predicts progression to renal failure and should be adopted in clinical practice Haematologica The International Society Of Amyloidosis haematologica.org/article/downlo…

🫘Suspecting ATIN in AKI? Biopsy or biomarkers? This sharp flowchart 🧾makes it simple! 🚨Don’t miss CXCL9, IL9, TNFα & PET-CT’s role in avoiding unnecessary biopsies 📖 doi.org/10.1016/j.ekir… #Nephrology #MedTwitter #AKI #ATIN #MedEd #Biomarker

Anti #Rituximab Antibodies Occurrence and Clinical Outcomes in Patients With Primary #MembranousNephropathy #VisualAbstract by Susan Thanabalasingam kireports.org/article/S2468-… Marco Allinovi

Just out: FDA grants accelerated approval to linvoseltamab for treatment of relapsed/refractory myeloma. It is the 3rd BCMA bispecific antibody approved for myeloma. I welcome the choice that patients and physicians have. ajmc.com/view/fda-appro…

Anti-tubular basement membrane (TBM) disease 🔸Rare type of tubulointerstitial nephritis 🔸Strong linear polyclonal IgG restricted to TBMs 🔸No deposits by EM 🔸Autoantibody to TIN-ag in proximal TBM 🔸AKI/CKD, polyuria, polydipsia #renalpath #PathTwitter (1/2)

15% of patients undergoing partial nephrectomy experienced "subclinical AKI" (urinary NephroCheck >0.3 and creatinine increase <0.3 mg/dL), a condition characterized by acute tubular stress/damage and related to an increased risk of 24-month eGFR decline. rdcu.be/euosU