Congrats to the Waterfield lab on this newly identified regulator of thymic tolerance.Diabetes Center at UCSF UC San Francisco Ikaros is a principal regulator of Aire+ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance | Science Immunology science.org/doi/10.1126/sc…

Excited to share new collaborative work in Nature on the genetic underpinnings of COVID susceptibility that is linked to a defect in the thymus. Great thanks to my colleagues in the Casanova, Puel, and DeRisi labs! Diabetes Center at UCSF UCSF Bakar ImmunoX Initiative UC San Francisco nature.com/articles/s4158…

Ready for a masterpiece! Jointly led by Drs. Anne Puel, Jean-Laurent Casanova (Casanova Lab), Mark Anderson, and Luigi Notarangelo, this nature study talks about autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency. bit.ly/474hpho

Congrats to Tang Lab Postdoc Roberto Castro Gutierrez for being named a 2024 California Institute for Regenerative Medicine Scholar

Congrats to Elze and our team that have developed a new powerful tool to assess the specificity of autoimmunity in mouse models. Diabetes Center at UCSF UCSF Bakar ImmunoX Initiative UC San Francisco doi.org/10.1172/jci.in…

New in nature: #COVID patients with specific mutations in NFKB2 gene develop antibodies to type I interferons, which are associated with a severe disease course, often involving hospitalization and ICU care. 🧵 1/5

Finalize & Submit your abstract ahead of time ✔️ There's only 3 days remaining to submit your research and be a part of the FOCIS 2024 Annual Meeting! Don't wait - submit today ⏳: ow.ly/nH5T50QrTrb

Congrats to Mianmian and Tony on this important collaborative work on thymic selection of autoreactive T cells! Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model | PNAS pnas.org/doi/10.1073/pn…

Excited to be part of a team that identified a rare family with a defect in PDL1 that has a strong link to type 1 diabetes and other immune dysregulation. rupress.org/jem/article/22…

Here is some fascinating Helmsley Charitable Trust funded science from Richard Oram Mark Anderson Andrew Hattersley and many others that discovers a rare PD-L1 genetic variant and shows how the PD-1 pathway is a high priority drug target to prevent/delay #T1D. Veera Rajagopal  rupress.org/jem/article/22…

Excited to share some new collaborative work with the Kappler lab on how thymic tolerance to insulin is maintained in a model of T1 Diabetes. Aire mediates tolerance to insulin through thymic trimming of high-affinity T cell clones | PNAS pnas.org/doi/10.1073/pn…

"Decoding gene regulation with CRISPR perturbations" by McManus Lab @ UCSF postdoc Stefan Oberlin published in Nature Biotechnology

Excited to share new collaborative work on the autoreactome that just came out in JCI jci.org/articles/view/…

Honored and thrilled for this recognition

Great piece on all of the excitement around Ozempic and GLP-1 agonists. Great job Suneil!

Insights: Cindy Ma & Stuart Tangye discuss new study from Megan Cooper (hubs.la/Q02F282T0) that proposes a role for dysregulated IL-22 production by Th17 cells in causing some aspects of immune-mediated skin inflammation in #STAT3GOF syndrome. hubs.la/Q02F26zv0

Congrats to our team in the UCSF Diabetes Center!

Early in the pandemic, kids were hospitalized with a mysterious disease, MIS-C. A team led by Aaron Bodansky, MD Mark Anderson Chan Zuckerberg Biohub Network discovered how mild COVID led to MIS-C, hinting at what might go wrong in autoimmune diseases like #MS. Boston Children's News & Research @stjude tiny.ucsf.edu/ArB6Z7

Proud of our team that unlocked this terrible complication of COVID-19 in children. Diabetes Center at UCSF UC San Francisco UCSF Bakar ImmunoX Initiative nature.com/articles/s4158…

Scientists Get to the Bottom of COVID’s Worst Pediatric Complication ucsf.edu/news/2024/08/4…