Do you want to know about using DNA methylation to study cell identity, proliferation, genome activation history, or tumor cell of origin in single cells? Check out our review! frontiersin.org/articles/10.33… #DNAmethylation #SingleCell #hematopoiesis

I am super excited to present our recent preprint on Deep Indel Mutagenesis at this year’s #ASHG23, just a few days away! 🤩 📅2nd of November (11.30-11.45am ET) 👉Session 23: Systematic analysis of variant functions 📰 biorxiv.org/content/10.110…

Very happy to share what I've been working on in Barcelona with Ben Lehner ! We made many (>400k) mutations in a disordered peptide and the globular domain it interacts with to gain a comprehensive map of how specificity is encoded in a partially fuzzy protein interaction (1/n)

The allosteric landscape of the Src kinase. Amazing work from @ToniBeltran13 with Andre Faure @ajfaure.bsky.social biorxiv.org/content/10.110… Centre for Genomic Regulation (CRG) Wellcome Sanger Institute

Introducing the Domainome... Site saturation mutagenesis of 500 human protein domains reveals the contribution of protein destabilization to genetic disease by @ToniBeltran13 Centre for Genomic Regulation (CRG) Wellcome Sanger Institute BGI Genomics biorxiv.org/content/10.110…

I’m super happy to finally share what I have been up to the last few years at the Ben Lehner lab in Barcelona! We made lots of double mutants on the kinase domain of Src to study allosteric communication.

Excited to share Albert Escobedo's randomisation of protein cores at scale: Genetics, energetics and allostery during a billion years of hydrophobic protein core evolution with Andre Faure @ajfaure.bsky.social Centre for Genomic Regulation (CRG) Wellcome Sanger Institute biorxiv.org/content/10.110…

A much improved version of this, today out in Nature Genetics ! with Ben Lehner and Fran Supek nature.com/articles/s4158…

A major challenge in treating rare genetic diseases is the huge number of causal variants in different individuals. This led to assumptions that any given treatment would be suitable only for a small fraction of patients