🎶 Ludwig van Beethoven, one of the most celebrated musicians in human history, has a low genetic predisposition for "musicality". We discuss challenges of polygenic score predictions at the individual level, and for someone who lived over 200 years ago: authors.elsevier.com/sd/article/S09…

Blended Genome Exome (BGE) as a Cost Efficient Alternative to Deep Whole Genomes or Arrays biorxiv.org/content/10.110…

Two new chapters from my open-access textbook in human population genetics are now online: - Population structure: I. Ancestry estimation - Population structure: II. More about admixture web.stanford.edu/group/pritchar…

New pre-print from the PGC Consortium #Depression Group: Multi-ancestry GWAS of depression with 685,000 cases identifies 697 independent associations, implicating known & novel drug targets. 🔗 medrxiv.org/content/10.110… 1/n

Analysis of previously unstudied areas of the human genome suggests people with more copies of ribosomal DNA have higher risks of developing disease. 🔗 Read more: bit.ly/3QJSkCa david_mf_evans

The Mental Elf has received a 3-year discretionary award from the Wellcome, to continue running the website as we have been doing for the last few years. Thank you to @niallpboyce Prof Miranda Wolpert for this amazing show of support! ❤️ Read more: nationalelfservice.net/mental-health/…

Excited to share our latest preprint introducing SAIGE-QTL, a powerful tool for single-cell eQTL analysis! Check it out here: medrxiv.org/content/10.110… #eQTL #scRNAseq #genomics (1/9)

Do you calculate #polygenic scores? Is it tedious and time-consuming? Try GenoPred! Easily installed, reproducible analysis, single command line. Choice of analysis methods, diverse ancestries.

Very special outing to Kew Gardens to celebrate EDIT Lab KCL & TEDS teams winning the Institute of Psychiatry, Psychology & Neuroscience Open Science award. Particularly enjoyed visiting the #DNA helix sculpture. Great to have our two visitors Madhur Bain Singh and Brittany Mitchell with us too. SGDP Centre KCL

1/5 POP-GEM Lab members are at #BGA2024 in London to participate in a symposium on "Illuminating Phenotypic Interconnections: Insights from Biobanks and Statistical Genetic Approaches"🗓️ 6/28 13:30 to 15:10 Dr. Rosie Tim Bigdeli Madhur Bain Singh @RachelKember 🧬See below👇

I will be looking to take a new Clinical Psychology PhD student this upcoming year at VCU Psychology. Students who are interested in PTSD, alcohol and drug use comorbidity, genetics, and mechanistic studies are encouraged to apply! Colleagues, please send me your students!

Join us for our next Members' Meetup, where we will: 1. Provide an overview of the Tractor method and its underlying theory. 2. Offer a live demonstration, from installation to interpretation of results. 3. Conduct a Q&A session ispg.net/members-meetup…

Postdoctoral role in statistical genetics at NIHR Maudsley Biomedical Research Centre (BRC) & SGDP Centre KCL. Research in genetics and polygenic scores, to advance care for mental disorders. Collaborative projects, good for a new PhD with comp. & stat skills. Please RT! kcl.ac.uk/jobs/095205-po…

The GenoPred Pipeline: A Comprehensive and Scalable Pipeline for Polygenic Scoring from Oliver Pain is now online. Github & manual: opain.github.io/GenoPred/ Video: youtube.com/watch?v=dKiG8U… academic.oup.com/bioinformatics…… One-step polygenic score calculations NIHR Maudsley Biomedical Research Centre (BRC)

3/3💡 Madhur Bain Singh also sharing research on MDD from cross-ancestry genome-wide analyses in the UK Biobank! Discover enhanced genomic insights into major depressive disorder. 🗓️ 10/16 | 🕐 1:15 - 1:30 PM 🧠 #Psychiatry #GeneticsResearch

5/5📢 Join Dr. Rosie at #WCP2024 for “Empowering Genomic Discovery for Major Depression: A GWAS Workflow Across Ancestries”! 🌎 Catch it on 11/17, 12-1 PM, Station 1. Advancing trans-ancestry GWAS for genetic insights! 💡 #Genetics #Psychiatry SUNY Downstate

Thrilled to share some amazing news— Madhur Bain Singh, supervised by Dr. Rosie & Richard Mcneale, has been awarded VIPBG at VCU 's Kenneth S. Kendler Award for Excellence in Predoctoral Research!

🚀New paper by Madhur Bain Singh on smoking & DNA methylation via twin-based MR using Netherlands Twin Register data! Supervised by Michael C Neale, Jenny van Dongen, & Conor Dolan. Co-authors: Dr. Rosie, Dana Lapato, Charles Breeze, gibran hemani, Hermine Maes. 🔗 doi.org/10.1007/s10654…

Nice paper showing ~1/540 people have a sex chromosome trisomy from 3 large biobanks (UKB, FinnGen, MVP) comprising 1.5 million individuals along with their phenotypic impact. medrxiv.org/content/10.110…

🚨New paper alert!🚨 Using triangulated evidence, Kirsten van Hooijdonk, Jacqueline Vink & team (Zoe Reed, Madhur Bain Singh, Hannah Sallis, Marcus Munafò) find no bidirectional causal links between diet/physical activity & depression/anxiety. 🔬❌ 📖 Read more: doi.org/10.1017/S00332…