Proud to share our latest work in Biophysical Journal authors.elsevier.com/a/1gW271SPT41la Nanodiscs are an exciting technology for studying membrane proteins in lipid bilayers. We asked whether nanodisc bilayers preserve the native properties of intact lipid membranes. And the answer is… NO! 1/2

Great to see our story led by David Kern on LRRC8A:C volume regulated anion channels in its final form! Lots of new data since the preprint including structures of a mutant that disrupts lipid block of the pore to activate the channel rdcu.be/c7MWW nature.com/articles/s4159…

Check out our latest work published in Nature Communications. Congrats to Christian Tessier , Johnathon Emlaw, and Mich for all the hard work. nature.com/articles/s4146…

Where do new senses come from? In paired studies, we explore the structural basis of sensory receptor evolution in octopus and squid. @CoreyAHallard Wendy Valencia @RyanHibbs10 nature - nature.com/articles/s4158… - nature.com/articles/s4158…

I am excited to share that the paper from my Ph.D. work in the Hibbs lab is out in Nature Communications today. It was a great experience working on this project with @RyanHibbs10, Mahfuz Rahman, and Jinfeng Teng. nature.com/articles/s4146… UTSW Graduate School of Biomedical Sciences The Department of Biophysics at UT Southwestern

Structural Determinants for Activity of the Antidepressant Vortioxetine at Human and Rodent 5-HT3 receptors | bioRxiv biorxiv.org/content/10.110…

Our new paper was just published! Check it out 😍 nature.com/articles/s4146…

Kudos to John Baenziger & his uOttawa | Faculté de médecine, Faculty of Medicine team for more impactful insights into a key receptor that is implicated in neurological and neuromuscular diseases including #Alzheimer’s & #Parkinson’s. 🙌

Excited to share our latest collaboration with the @corrylab and Zhang Lab, this time on OSCA/TMEM63 channels out today in nature Victor Chang Cardiac Research Institute nature.com/articles/s4158…

Membrane tension is hard to measure, as you need to know the radius of the membrane to calculate it from the applied pressure (Laplace’s law). This paper uses patch clamp and imaging to quantify membrane tension dependence of TRAAK and TREK K+ channels. nature.com/articles/s4146…

Check out our new paper quantifying tension activation of mechanosensitive K2P channels by pressure + ultrasound co-led by Ben Sorum and Trevor Docter! Lots of new data to see since the preprint last year including a comparison of TRAAK, TREK1, and TREK2 nature.com/articles/s4146…

Structural switch in acetylcholine receptors in developing muscle | Nature doi.org/10.1038/s41586…

Collaborative effort by John Baenziger, Hugues Nury, and daCostaLab. Congrats to Mackenzie Thompson for leading the cryo-EM work and Christian Tessier for leading the single-channel recordings. Happy to have contributed.

Excited to share our latest publication: "Asynchronous subunit transitions precede acetylcholine receptor activation" biorxiv.org/content/10.110…

Congrats to Mackenzie Thompson for the crowning achievement of his PhD. Thanks to my outstanding collaborators: Eleftherios Zarkadas, Hugues Nury , daCostaLab , François Dehez, and the many outstanding trainee contributors: Christian Tessier, Anna Ananchenko, and Johnathon Emlaw

A new publication from John Baenziger lab reveals a sequential activation mechanism for the Torpedo nAChR! These new structures show how #nAChR subunits transition between unliganded to mono- and di-liganded conformations upon agonist binding.

Excited to share our latest collaborative effort posted on bioRxiv. The combined power or single-molecule structure and function... All in one package! Thanks to all our great collaborators! biorxiv.org/content/10.110…

Asynchronous subunit transitions precede acetylcholine receptor activation | bioRxiv biorxiv.org/content/10.110…

Structures of the human adult muscle-type nicotinic receptor in resting and desensitised states biorxiv.org/cgi/content/sh… #biorxiv_neursci