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In defense of basic science - my new video about how we balance basic vs. translational science: youtu.be/yl6ETxRfQn8?si…. . And why we should encourage a culture of wandering to solve problems:. A team effort between University of Oxford and OxfordSparks.

Paper alert 📚 Neural progenitor–derived Apelin controls tip cell behavior and vascular patterning Excited to share my PhD's work, many thanks to all members of the Helker lab Lab and Kazuhide Shaun Okuda and Ben Hogan for the help! science.org/doi/10.1126/sc…

It turns out...Komodo dragons have iron-coated teeth! nature.com/articles/s4155… Their serrations and tips pop into the mouth with an orange hue. Using different techniques, we show that these iconic lizards have special iron-rich coatings on each tooth, keeping them razor sharp!

Unexpected, challenging dogma: gene expression is driven by DNA sequence variants with little contribution by methylation nature.com/articles/s4158… Nature Genetics deCODE genetics Oxford Nanopore

I am very happy to announce the publication of my main PhD project in Nature Communications . Our study demonstrates that Regulatory T cells (Tregs) play a crucial role in promoting cardiac repair following myocardial infarction (heart attack) by adopting an injury-specific phenotype.

Excited to see this study led by D'Juan Farmer finally come out after 1.5 years of revisions. My favorite part of the paper is the grem1a:nlsEOS line he made that beautifully lights up the sutures just as they are starting to form. D'Juan Farmer nature.com/articles/s4146…

This meeting HHMI | Janelia will bring together researchers to share challenges and successes in the development of new genetic tools for a broad range of non-traditional model organisms and biological problems. Learn more + apply by Oct. 29 @ janelia.news/NMS25 @HHMINews

New paper alert 📰 Beyond excited to share the latest work from our lab by first author Dorothee Bornhorst at Nature Communications ! nature.com/articles/s4146… The heart is a resident tissue for hematopoietic stem and progenitor cells in zebrafish

My favorate piece of my postdoc work is published! We fused our favorite TFs with a deaminase domain that induces point mutations in DNA, mutagenizing TF binding sites across the genome. Will be a great reagent for exp. evo., as its name suggests :) academic.oup.com/mbe/article/41…

Happy to share that our preprint on using chimeric eCLIP to map snoRNA interactions (and find new non-canonical snoRNA:RBP subnetworks) is now up! A fun collaboration with the great Amanda Whipple lab, and great work by Joey, Min, and others! biorxiv.org/content/10.110…

A 1,000,000th reminder the crucial importance of basic research. Ambros and Ruvkun were looking into understanding nematode genetics and development, not looking for a drug, and ended up opening an entire new area in biology

The life of each one of us began when a sperm and an egg came together. But what actually happens at a molecular level? Our latest work @PauliGroup Cell Press reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/8) cell.com/cell/fulltext/…

📡🧵 Excited to release two #bioRxiv preprints! The first preprint is: "Zebrahub-Multiome: Uncovering Gene Regulatory Network Dynamics During Zebrafish Embryogenesis" doi.org/10.1101/2024.1… We present a comprehensive time-resolved single-cell multiomic atlas of zebrafish

Excited to share our team's discovery on tissue-like multicellularity in archaea under mechanical compression! Led by theopi, Olivia Leland & Alex Bisson, it rethinks the evolution of multicellularity beyond eukaryotes. HFSP @MPI_Bio biorxiv.org/cgi/content/sh…

The ability of the animal body to self-assemble based on information encoded in our genomes is one of the most remarkable miracles of the living world. We now take for granted the idea that shared cellular machinery mediates this & read textbooks laying outmolecular details 1/n

Does the aggregation of complex multicellularity follow a universal developmental pattern across the eukaryotic tree of life? Thrilled to announce that we found a convergently evolved transcriptomic hourglass pattern in brown algal development. nature 👉nature.com/articles/s4158…

3/4 We also observed striking reprogramming of neural crest cells to a mesoderm-like state, resulting in ectopic fins throughout the body. EWSR1::FLI1 hijacked the developmental program that included activation of HOX genes and FGFR signaling cascades during the formation of