Direct comparison of four methods for #CRISPR off-target detection. What pros and cons of the different methods can you tell? Read here: [rdcu.be/cRxJP]

SURRO-seq for the simultaneous investigation of thousands of off-targets sites for therapeutic RNA-guided nucleases in cells. go.nature.com/3OaangA

2013 resistance to many viruses. 2022 resistance to all natural viruses. The method should work for any host. biorxiv.org/content/10.110…

Today we report in Nature Biomedical Engineering the development of a suite of adenine based editors (ABEs) that are small enough to each fit, together with a guide RNA & all needed regulatory elements, into a single AAV to support efficient base editing in animals. 1/4 drive.google.com/file/d/1FdAF4i…

A excitingly new version of the single cell type atlas from SciLifeLab and Human Protein Atlas is released. Genome-wide single cell annotation of the human protein-coding genes biorxiv.org/content/10.110…

Our trial of NRPT during muscle injury in elderly subjects is now published in @JCI_Insight 32 subjects volunteered to experimental muscle injury+5 muscle biopsies. All subjects recovered completely but NRPT didn’t help insight.jci.org/articles/view/… #nicotinamideriboside #myotwitter

Group picture in Brussels of the launching of this COST action CA21113 #GenEHumdi on Genome Editing to Treat Humans Diseases, led by Karim Benabdel Lah El Khlanji GENYO with the administrative support of María Bazuelo from Fundación Progreso y Salud cost.eu/actions/CA2111…

Happy to share our new EC atlas results with ⁦CarmelietLab⁩, which we identify lipid-processing and immunomodulatory EC subtypes in breast (cancer) tissues, published in ⁦Nature Communications⁩. nature.com/articles/s4146…

A compendium of genetic regulatory effects across pig tissues biorxiv.org/cgi/content/sh… #biorxiv_genomic

The PigGTEx resource is out now (piggtex.farmgtex.org). Congratulations to Lingzhao Fang QGG AU and the global team. Here is the BioRxiv version: biorxiv.org/content/10.110…. Hope you enjoy it. Please help spread it widely. Thanks!

Truly terrific results (PigGTEx) from the Farm animal Genotype-Tissue Expression (FarmGTEx, farmgtex.org) project is now published bioRxiv. An impressive endeavour led by Lingzhao Fang and the FarmGTEx consortium. A new kid on the block. biorxiv.org/content/10.110…

Check out my interview for the EACR Travel Fellowship I was awarded for a 3-month collaboration in Dr. DREAMlab lab at Aarhus University in the EACR online magazine! magazine.eacr.org/i-am-really-gl… Thanks to my PI Dr. Denis Collins, @scienceirel and @PumaBiotech

A DNA chapter of “The Lord of the Rings”!

We continue with #kickoff_meeting Cost Action GenE-Humdi GENYO Fundación PTS (Parque Tecnológico de la Salud) sharing different delivery strategies for #geneediting WG3 DREAMlab Aarhus University karim benabdellah GENYO #AShambach mh-hannover #RNair Kavli Neuroscience NanoChemBio #DrPengLing CNRS 🌍 @univAMU_Europe

A new version of pig single cell atlas is available: Construction of a multi-tissue cell atlas reveals cell-type-specific regulation of molecular and complex phenotypes in pigs. FarmGTEx biorxiv.org/content/10.110…

Read our #preprint on Research Square: Single cell analysis of epithelial, immune, and stromal signatures and interactions in human ovarian cancer researchsquare.com/article/rs-302…

Discovery of new deaminase functions by structure-based protein clustering biorxiv.org/content/10.110…

We are excited to share our STOP-CKD resource with the entire society!!! STOP-CKD stands for Spatial-Temporal transcriptOmic Profiling of Chronic Kidney Disease. dreamapp.biomed.au.dk/STOP_CKD/. This a beta version, which is not peer-reviewed or published. Any comment is welcome.

Excited to share this hallmark study from Research @ Steno Diabetes Center Aarhus led by Jean Farup, Niels Jessen, unraveling the repair of elderly human skeletal muscle with spatial transcriptomics. biorxiv.org/content/10.110…

👉🏻Check out how #CRISPR is applied for Generative Modelling of Oncogene-carrying Extrachromosomal Circular DNA Biogenesis and Dynamics in Cells. Regenberg Laboratory at University of Copenhagen biorxiv.org/content/10.110…