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Enjoyed writing this chapter exploring 'Opioid Mechanisms and the Treatment of Depression' link.springer.com/chapter/10.100… @mehta_mitul72

There are lots of interesting stories in the data. Thanks to various people on Twitter who pulled out some of the trends I pointed to in the write-up. Including Michael Absoud, Luke Jelen,Luke O'Shea, Peter Sivey, Tom Ellis. Keen to see what people find next!

With all the holiday chaos, I hadn’t shared. Our big collaboration is out now in Molecular Psychiatry “Unique pharmacodynamic properties and low abuse liability of the μ-opioid receptor ligand (S)-methadone”! One of my favorite Christmas gifts this year 1/ rdcu.be/duqdR

Happy New Year and Happy New Preprint! 🎉Excited to share the 2nd paper from my PhD - looking at the effects of the GABA-enhancing drug diazepam 💊 on hippocampal hyperactivity 🧠⬆️ in people at clinical high-risk for psychosis. Some exciting results! medrxiv.org/content/10.110…

A true hero ❤️! Congrats to Charles Bowman

The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions nature.com/articles/s4139…

📢 Super excited to have a project available in the 2024 NIHR Maudsley Biomedical Research Centre (BRC) PhD studentships, using 7T MRI to investigate glutamate & GABA dynamics in schizophrenia 🤩 Supervised by Prof Alice Egerton, Dr Nick Puts & me! Applications open! Project CO24-001: maudsleybrc.nihr.ac.uk/academic-caree…

**Unintentional Ketamine overdose via Telehealth**. 1.2g (20.6mg/kg) dose prescribed sublingually but taken orally. US ketamine prescribers- how common is to prescribe such a dose?! Far and above the max we would regularly prescribe in the UK.

Can we have Gary Stevenson as a guest on BBC Question Time please? #bbcqt m.youtube.com/watch?v=jFHGiq…

We are recruiting to a new 2 year research post in mood disorders - details here! kcl.ac.uk/jobs/085825-re…

We have recently treated two cases of treatment refractory mania, that after decades of quality life lost due to inadequate pharmacological treatment both demonstrated profound response to ECT. We are writing up to support the view ECT should be used sooner rather than later

Great work Boris D Heifets and team! More on Ketamine +/- Naltrexone mechanisms (in humans) soon(ish) 👀

Tragically spot on

🚨PhD Studentship Available!🚨 Join our lovely team Institute of Psychiatry, Psychology & Neuroscience & a super cool project using 7T MRI to investigate glutamate & GABA dynamics in schizophrenia 🧠 Supervised by Prof Alice Egerton, Dr Nick Puts & me! 🚀 Deadline 12th August - pls share! maudsleybrc.nihr.ac.uk/academic-caree…

I want to highlight a finding from (tinyurl.com/37n77d9b) that IMO did not receive enough attention in #psychedelic trial geek circles: it shows that the #placebo effect is much smaller in psychedelic #depression trials than in trials with traditional #antidepressants

Published today in Lancet Psychiatry, after 7 years of hard labour... the first long-term head-to-head comparison of two augmentation treatments in treatment resistant depression. Clinical and cost-effectiveness of lithium versus quetiapine augmentat... sciencedirect.com/science/articl…