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Combining spatial transcriptomics and ECM imaging in 3D for mapping cellular interactions in the tumor microenvironment: Cell Systems cell.com/cell-systems/f…

🚨We're hiring at Institute of Biotechnology🚨 Join the GliaOmics Lab and dive into cutting-edge single-cell & spatial transcriptomics in stroke research. 🔬 Postdoc & PhD student ⏳ Short deadline: April 27 & May 12 📍 BIOCEV_SCIENCE, near Prague 🔗 tinyurl.com/2u7umwjr 🔁 Please share or RT!

🚀 Our perspective is out in nature! We present a roadmap for Multimodal Foundation Models (MFMs) — large AI models pretrained across multi-omics and multi-timepoint data — to serve as the computational backbone for building virtual cells. Read the full paper in Nature:

🚨 New paper: Much of stroke research focuses on acute injury - but what changes in the brain one month after stroke? We mapped cellular and molecular shifts in the brain during the repair phase | J Neuroinflammation BMC 🧬🧠 👇

Easydecon: A Lightweight Workflow for Cell Type Analysis in High-Definition Spatial Transcriptomics Assays biorxiv.org/content/10.110…

A Practical Guide to Spatial Transcriptomics: Lessons from over 1000 Samples🫶 preprints.org/manuscript/202…

1/ Excited to share CellFlow, a new approach for complex perturbation modeling in single-cell genomics based on flow matching. From cytokine screens to cell fate and organoid engineering, we show CellFlow’s broad power across many diverse tasks. 👉 Paper: biorxiv.org/content/10.110…

Bruker’s nCounter is evolving! Now analyze RNA & protein from the same sample in one run—FFPE compatible, stackable 200-300 plex protein + gene panels, integrated analysis. Visit us at AACR Booth #2320 👉 brukerspatialbiology.com/aacr-2025 #AACR2025 #multiomics #nCounter

Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration biorxiv.org/content/10.110…

From Transcripts to Cells: Dissecting Sensitivity, Signal Contamination, and Specificity in Xenium Spatial Transcriptomics biorxiv.org/content/10.110…

It was fun to learn about blood vessel organoids together with Marina Nikolova and Treutlein lab! Thanks to Reiner Wimmer and PenningerLab for introducing us to this system! cell.com/cell/fulltext/…. Great support from editors and reviewers Cell!

Neuropathological hallmarks during the chronic phase of ischemic stroke in mice and humans biorxiv.org/content/10.110…

Chimeric brain models: Unlocking insights into human neural development, aging, diseases, and cell therapies cell.com/neuron/abstrac…

So cool!🤯

How the Human Cell Atlas is fast-tracking new medicines😍 npr.org/2025/04/18/g-s…

F.O.R.W.A.R.D: A Data-Driven Framework for Network-Based Target Prioritization in Drug Discovery biorxiv.org/content/10.110…

Pleased to see our perspective with ⁦Leon Smyth⁩ now online || Redefining CNS immune privilege | Nature Reviews Immunology nature.com/articles/s4157…

Type I interferon signalling and interferon-responsive microglia in health and disease febs.onlinelibrary.wiley.com/doi/10.1111/fe…

Supervised and unsupervised learning reveal heroin-induced impairments in astrocyte structural plasticity science.org/doi/full/10.11…

Heterogeneity in pericyte inflammatory responses across age and species highlight the importance of human cell models molecularbrain.biomedcentral.com/articles/10.11…